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Trazodone is a 5-HT 1A receptor partial agonist similarly to buspirone and tandospirone but with comparatively greater intrinsic activity. [90] [107] [108] A range of weak affinities (K i) have been reported for trazodone at the human histamine H 1 receptor, including 220 nM, [90] 350 nM, [105] 500 nM, [109] and 1,100 nM. [94]
Rare (<0.1%) adverse effects include: Urinary retention; Prolonged QT interval; Torsades de Pointes; Ataxia; Breast enlargement or engorgement; Lactation; Cardiospasm
Chemical structure of the prototypical NaSSA mirtazapine (original brand name Remeron). Noradrenergic and specific serotonergic antidepressants (NaSSAs) are a class of psychiatric drugs used primarily as antidepressants. [1]
Keppra (levetiracetam) – an anticonvulsant drug which is sometimes used as a mood stabilizer and has potential benefits for other psychiatric and neurologic conditions such as Tourette syndrome, anxiety disorder, and Alzheimer's disease; Klonopin – anti-anxiety and anti-epileptic medication of the benzodiazepine class
Most but not all values are for human proteins. These drugs act as antagonists or inverse agonists of the 5-HT 2A , α 1 -adrenergic, and H 1 receptors, as partial agonists of the 5-HT 1A receptor, [ 3 ] and as inhibitors of the transporters. mCPP is an antagonist of the 5-HT 2B receptor, an agonist of the 5-HT 1A , [ 3 ] 5-HT 2C , and 5-HT 3 ...
Post-SSRI sexual dysfunction (PSSD) [63] [64] refers to a set of symptoms reported by some people who have taken SSRIs or other serotonin reuptake-inhibiting (SRI) drugs, in which sexual dysfunction symptoms persist for at least three months [65] [66] [67] after ceasing to take the drug. The status of PSSD as a legitimate and distinct pathology ...
Just 100 micrograms of MM120 led to a 48% rate of remission from generalized anxiety disorder after 12 weeks, MindMed reported. Single dose of LSD can cut anxiety in half within weeks ...
Benzodiazepine withdrawal syndrome (BZD withdrawal) is the cluster of signs and symptoms that may emerge when a person who has been taking benzodiazepines as prescribed develops a physical dependence on them and then reduces the dose or stops taking them without a safe taper schedule.
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