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However, salivary tumors show a great deal of morphological diversity, as well as variations in the nature of the lesion (malignant vs. benign): approximately 20% to 25% of parotid tumors, 35% to 40% of submandibular tumors, and more than 90% of sublingual gland tumors are malignant. [8]
The most common causes of enlargement of the submandibular lymph nodes are infections of the head, neck, ears, eyes, nasal sinuses, pharynx, and scalp. [1] The lymph glands may be affected by metastatic spread of cancers of the oral cavity, anterior portion of the nasal cavity, soft tissues of the mid-face, and submandibular salivary gland. [1]
Around 50% of the tumours found in the submandibular glands are benign. Sublingual gland tumours are very rare but if present, they are most likely to be malignant. [ 3 ] [ 18 ] Saku et al. in 1997 [ 19 ] and Venturi [ 20 ] [ 21 ] in 2021, reported the causal role for ionizing radiation in salivary gland tumorigenesis, particularly for ...
1.5.3 MeSH D23.125.585 – chemotactic factors, macrophage 1.5.4 MeSH D23.125.685 – n-formylmethionine leucyl-phenylalanine 1.6 MeSH D23.348 – growth substances
2: Submandibular lymph nodes 3: Supraclavicular lymph nodes 4: Retropharyngeal lymph nodes 5: Buccinator lymph node 6: Superficial cervical lymph nodes 7: Jugular lymph nodes 8: Parotid lymph nodes 9: Retroauricular lymph nodes and occipital lymph nodes
[10] [14] Periapical abscesses of these teeth also result in lingual cortical penetration, leading to submandibular infection. [ 10 ] Other causes such as oral ulcerations, infections secondary to oral malignancy, mandible fractures, sialolithiasis-related submandibular gland infections, [ 10 ] and penetrating injuries of the mouth floor [ 15 ...
A study done on the epidemiology of sialadenitis in the United States of America found that acute suppurative parotitis is responsible for 0.01–0.02% of hospital admissions, with the submandibular gland accounting for 10% of cases of sialadenitis in the major salivary glands in this population. [1]
Rarely, removal of the submandibular gland may become necessary in cases of recurrent stone formation. Sialolithiasis is common, accounting for about 50% of all disease occurring in the major salivary glands and causing symptoms in about 0.45% of the general population. Persons aged 30–60 and males are more likely to develop sialolithiasis. [2]