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An equianalgesic chart is a conversion chart that lists equivalent doses of analgesics (drugs used to relieve pain). Equianalgesic charts are used for calculation of an equivalent dose (a dose which would offer an equal amount of analgesia) between different analgesics. [1]
The procedure is to take the child's weight in pounds, divide by 150 lb, and multiply the fractional result by the adult dose to find the equivalent child dosage.For example, if an adult dose of medication calls for 30 mg and the child weighs 30 lb, divide the weight by 150 (30/150) to obtain 1/5 and multiply 1/5 times 30 mg to get 6 mg.
In animal studies, the median lethal dose (LD 50) of modafinil varies among species and depends on the route of administration. In mice and rats, the LD 50 is approximately 1250 mg/kg if administered via an injection, but the oral LD 50 for rats is 3400 mg/kg. [131] [132] The LD 50 value for humans have not been established.
A massive recall of children's Benadryl issued today by McNeil Consumer Healthcare is reminding parents and consumers that the long-playing saga of quality problems with popular over-the-counter ...
Inadequate pain management in children can lead to psychosocial consequences, including lack of interest in food, apathy, sleep problems, anxiety, avoidance of discussions about health, fear, hopelessness, and powerlessness. Other consequences include extended hospital stays, high readmission rates, and longer recovery.
Children appear to be at a high risk for cardiopulmonary arrest. A toxic dose for children of more than 1.8 mg/kg has been reported. A 3-year-old child died 18 hours after ingesting 1,000 mg doxylamine succinate. [5] Rarely, an overdose results in rhabdomyolysis and acute kidney injury. [36]
The first patent for its use in circadian rhythm disorders was granted in 1987 to Roger V Short and Stuart Armstrong at Monash University, [60] and the first patent for its use as a low-dose sleep aid was granted to Richard Wurtman at MIT in 1995. [61] Around the same time, the hormone got a lot of press as a possible treatment for many ...
Nitrazepam in doses of 5 mg or more causes significant deterioration in vigilance performance combined with increased feelings of sleepiness. [32] Nitrazepam at doses of 5 mg or higher impairs driving skills [33] and like other hypnotic drugs, it is associated with an increased risk of traffic accidents. [34]