Search results
Results from the WOW.Com Content Network
This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. TALE homeobox proteins are highly conserved transcription regulators, and several members have been shown to be essential contributors to developmental programs.
4211 17268 Ensembl ENSG00000143995 ENSMUSG00000020160 UniProt O00470 Q60954 RefSeq (mRNA) NM_002398 NM_001193271 NM_010789 RefSeq (protein) NP_002389 NP_001180200 NP_034919 Location (UCSC) Chr 2: 66.43 – 66.57 Mb Chr 11: 18.83 – 18.97 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Homeobox protein Meis1 is a protein that in humans is encoded by the MEIS1 gene. Function Homeobox ...
Activation of gene transcription is a complex system of signal cascades and recruitment of necessary components such as RNA polymerase and transcription factors. IEGs are often the first responders to regulatory signals with many reaching peak expression within 30 minutes after stimuli compared to 2–4 hours in the case of delayed primary ...
MEF2, Myocyte Enhancer Factor 2, is a transcription factor with four specific numbers such as MEF2A, B, C, and D. Each MEF2 gene is located on a specific chromosome. MEF2 is known to be involved in the development and the looping of the heart (Chen) MEF2 is necessary for myocyte differentiation and gene activation (Black).
The mechanism of saRNA-mediated RNAa centers around the RNA-induced transcriptional activation (RITA) complex. [17] This complex includes: Argonaute 2 (AGO2): AGO2 binds to the guide strand of the saRNA and facilitates targeting to the gene promoter. AGO2 is the primary Argonaute protein involved in saRNA-mediated RNAa.
The gene atf2 is located at human chromosome 2q32. [6] The protein ATF-2 has 505 amino acids. Studies in mice indicate a role for ATF-2 in the development of nervous system and the skeleton. [7] ATF-2 is normally activated in response to signals that converge on stress-activated protein kinases p38 and JNK. [8]
Also, other studies propose that SHP-2 may increase JAK2 activity, and promote JAK2/STAT5 signalling. [50] It is still unknown how SHP2 can both inhibit and promote JAK-STAT signalling in the JAK2/STAT5 pathway; one theory is that SHP-2 may promote activation of JAK2, but inhibit STAT5 by removing phosphate groups from it. [38] CD45.
G protein activation causes a conformational change, which leads to the exchange of GDP for GTP. GTP-binding to the α-subunit causes dissociation of the β- and γ-subunits. [ 10 ] Furthermore, the three subunits, α, β, and γ have additional four main classes based on their primary sequence.