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Intercalated discs are complex structures that connect adjacent cardiac muscle cells. The three types of cell junction recognised as making up an intercalated disc are desmosomes, fascia adherens junctions, and gap junctions. [2] Fascia adherens are anchoring sites for actin, and connect to the closest sarcomere. [3]
Intercalated discs are part of the cardiac muscle cell sarcolemma and they contain gap junctions and desmosomes. The cardiac syncytium is a network of cardiomyocytes connected by intercalated discs that enable the rapid transmission of electrical impulses through the network, enabling the syncytium to act in a coordinated contraction of the ...
However, cardiac muscle cells contain a diad, which is a linking of only one sarcoplasmic reticulum with its respective t-tubule. Another notable distinction between all muscle cells and cardiac muscle cells is the presence of intercalated discs. These tight connections between the cardiomyocytes allows for the accelerated sending of action ...
Cardiac muscle cells are joined to neighboring cells by intercalated discs, and when joined in a visible unit they are described as a cardiac muscle fiber. [8] Smooth muscle cells control involuntary movements such as the peristalsis contractions in the esophagus and stomach. Smooth muscle has no myofibrils or sarcomeres and is therefore non ...
In adult cardiac muscle, N-RAP colocalizes to intercalated discs, [16] where it functions to anchor terminal actin filaments to the sarcolemma. It has been suggested that its role in adult muscle is force transduction from the sarcomere to the extracellular matrix.
Desmocollin-2 is widely expressed, and is the only desmocollin isoform expressed in cardiac muscle, where it localizes to intercalated discs. Mutations in DSC2 have been causally linked to arrhythmogenic right ventricular cardiomyopathy. [7]
Details of intercalated discs. Cardiomyocytes, are considerably shorter and have smaller diameters than skeletal myocytes. Cardiac muscle (like skeletal muscle) is characterized by striations – the stripes of dark and light bands resulting from the organised arrangement of myofilaments and myofibrils in the sarcomere along the length of the cell.
[5] [6] [7] Desmoplakin is a critical component of desmosome structures in cardiac muscle and epidermal cells, which function to maintain the structural integrity at adjacent cell contacts. In cardiac muscle , desmoplakin is localized to intercalated discs which mechanically couple cardiac cells to function in a coordinated syncytial structure.