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Primary mesenchyme is the first embryonic mesenchymal tissue to emerge, and it is produced from EMT in epiblast cells. In the epiblast , it is induced by the primitive streak through Wnt signaling , and produces endoderm and mesoderm from a transitory tissue called mesendoderm during the process of gastrulation .
Parietal epithelial cell (PEC) Podocyte; Angioblast → Endothelial cell; Mesangial cell. Intraglomerular; Extraglomerular; Juxtaglomerular cell; Macula densa cell; Stromal cell → Interstitial cell → Telocytes; Kidney proximal tubule brush border cell; Kidney distal tubule cell; Connecting tubule cells; α-intercalated cell; β-intercalated ...
The cells of the epiblast move toward the primitive streak and slip beneath it, in a process called "invagination". Some of the migrating cells displace the hypoblast and create the endoderm, and other cells migrate between the endoderm and the epiblast to create the mesoderm. The remaining cells form the ectoderm.
The mesoderm cells in the limb bud that come from the lateral plate mesoderm will eventually differentiate into the developing limb's connective tissues, such as cartilage, bone, and tendon. [3] Moreover, the mesoderm cells that come from the somites will eventually differentiate into the myogenic cells of the limb muscles. [3]
When neural cells migrate to the arches and surround them, they begin to increase in size. [4] The six pharyngeal arches give rise to much of the skeletal and muscular tissue in the head and neck region. When the embryo is 42 days old, the mesenchymal arches can be recognized with its corresponding cranial nerve. [1]
Limb formation results from a series of reciprocal tissue interactions between the mesenchyme of the lateral plate mesoderm and the overlying ectodermally derived epithelial cells. Cells from the lateral plate mesoderm and the myotome migrate to the limb field and proliferate to the point that they cause the ectoderm above to bulge out, forming ...
The lateral plate cells produce the cartilaginous and skeletal portions of the limb while the myotome cells produce the muscle components. The lateral plate mesodermal cells secrete a fibroblast growth factor (FGF7 and FGF10, presumably) to induce the overlying ectoderm to form an important organizing structure called the apical ectodermal ...
In contrast, transplantation of cells from the progress zone of a developing arm to replace the progress zone of a developing leg will produce a limb with leg structures proximally (femur, knee) and arm structures distally (hand, fingers). Thus it is the mesodermal cells of the progress zone, not the ectodermal cells of the AER, that control ...