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Buruli ulcer has been the subject of scientific research since the description of M. ulcerans in 1948, and the demonstration that the bacteria could cause ulcers in laboratory animals. [ 11 ] [ 54 ] While several animals are susceptible to M. ulcerans ulcers, mice (particularly BALB/c and C57BL/6 mice) are most commonly used to model Buruli ...
The bacteria can infect humans and some other animals, causing persistent open wounds called Buruli ulcer. M. ulcerans is closely related to Mycobacterium marinum , from which it evolved around one million years ago, and more distantly to the mycobacteria which cause tuberculosis and leprosy .
The Global Buruli Ulcer Initiative (GBUI) is a World Health Organization (WHO) initiative to coordinate global efforts to control Buruli ulcer, [1] an infectious disease characterized by the development of painless open wounds. [2]
This grows larger over days to weeks, forming an open ulcer (biopsy images pictured). Deep ulcers can cause scarring of muscles and tendons, resulting in permanent disability. The World Health Organization (WHO) recommends treating Buruli ulcer with a combination of the antibiotics rifampicin and clarithromycin. Regular cleaning and dressing of ...
Deep ulcers can cause scarring of muscles and tendons, resulting in permanent disability. Buruli ulcer is caused by skin infection with bacteria called Mycobacterium ulcerans . The mechanism by which M. ulcerans is transmitted from the environment to humans is not known, but may involve the bite of an aquatic insect or the infection of open wounds.
Buruli ulcer is caused by the bacterium Mycobacterium ulcerans. [34] It is related to the bacteria that cause tuberculosis and leprosy. Mycobacterium ulcerans produces a toxin, mycolactone, that destroys tissue. [34] The prevalence of Buruli ulcer is unknown. [18] The risk of mortality is low, although secondary infections can be lethal. [35]
Mycolactone is a polyketide-derived macrolide produced and secreted by a group of very closely related pathogenic mycobacteria species including M. ulcerans, M. liflandii (an unofficial designation), M. pseudoshottsii, and some strains of M. marinum.
Buruli ulcer (Bairnsdale ulcer, Searl ulcer, Searle's ulcer) Buruli ulcer; Erythema induratum (Bazin disease) Histoid leprosy; Lepromatous leprosy; Leprosy (Hansen's disease) Lichen scrofulosorum (tuberculosis cutis lichenoides) Lupus vulgaris (tuberculosis luposa)