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Mazindol is used in short-term (i.e., a few weeks) treatment of obesity, in combination with a regimen of weight reduction based on caloric restriction, exercise, and behavior modification in people with a body mass index greater than 30, or in those with a body mass index greater than 27 in the presence of risk factors such as hypertension, diabetes, or hyperlipidemia.
Plant extract sold as a dietary supplement: Contains ephedrine, an adrenergic agonist: Banned in 2004 for safety reasons 0.9 kilograms (2.0 lb) per month more than placebo [75] Amphetamine salts: Obetrol: Approved 1960, withdrawn 1973; Adderall was later approved for ADHD and narcolepsy and is still used for those purposes Phenylpropanolamine
Both medications have undergone testing and received approval by the U.S. Food & Drug Administration – Wegovy for targeting weight loss, and Ozempic for treating Type 2 diabetes.
Individually, naltrexone and bupropion each target pathways in the central nervous system that influence appetite and energy use. Bupropion is a reuptake inhibitor of both norepinephrine and dopamine , and a nicotinic acetylcholine receptor antagonist , and it activates proopiomelanocortin (POMC) neurons in the hypothalamus which give an effect ...
Green tea is thought to potentially help with weight management because of its main ingredients: catechins and caffeine, which may help increase metabolism and act as appetite suppressants.
Fenfluramine was an appetite suppressant which was used to treat obesity. [8] It was used both on its own and, in combination with phentermine, as part of the anti-obesity medication Fen-Phen. [8] In June 2020, fenfluramine was approved for medical use in the United States with an indication to treat Dravet syndrome. [7] [51]
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