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ALS is a motor neuron disease, which is a group of neurological disordersthat selectively affect motor neurons, the cells that control voluntary musclesof the body.[3] Other motor neuron diseases include primary lateral sclerosis(PLS), progressive muscular atrophy(PMA), progressive bulbar palsy, pseudobulbar palsy, and monomelic amyotrophy(MMA).
Multifocal motor neuropathy (MMN) is a progressively worsening condition where muscles in the extremities gradually weaken. The disorder, a pure motor neuropathy syndrome, is sometimes mistaken for amyotrophic lateral sclerosis (ALS) because of the similarity in the clinical picture, especially if muscle fasciculations are present.
The main symptom of benign fasciculation syndrome is focal or widespread involuntary muscle activity (fasciculation). [1] The benign twitches usually have a constant location. [2] Other common symptoms are generalized fatigue or weakness, paraesthesia or numbness, and muscle cramping or spasms. [1]
A fasciculation, or muscle twitch, is a spontaneous, involuntary muscle contraction and relaxation, involving fine muscle fibers. [1] They are common, with as many as 70% of people experiencing them. [1] They can be benign, or associated with more serious conditions. [1] When no cause or pathology is identified, they are diagnosed as benign ...
Specialty. Neurology, neuromuscular medicine. Neuromyotonia (NMT) is a form of peripheral nerve hyperexcitability that causes spontaneous muscular activity resulting from repetitive motor unit action potentials of peripheral origin. NMT along with Morvan's syndrome are the most severe types in the Peripheral Nerve Hyperexciteability spectrum.
Weakness can be symmetric or asymmetric, and it can occur in body parts that are distal, proximal, or both. According to Statland et al., there are three main weakness patterns that are seen in motor neuron diseases, which are: [6] [9] Asymmetric distal weakness without sensory loss (e.g. ALS, PLS, PMA, MMA)
ALS can manifest in people differently, but it usually starts with weakness that spreads or gets worse over time, according to the Mayo Clinic. Here are some of the symptoms of this fatal disease.
Disuse atrophy of the muscle occurs i.e., shrinkage of muscle fibre finally replaced by fibrous tissue (fibrous muscle) Other causes include Guillain–Barré syndrome, West Nile fever, C. botulism, polio, and cauda equina syndrome; another common cause of lower motor neuron degeneration is amyotrophic lateral sclerosis.