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ALS is a motor neuron disease, which is a group of neurological disordersthat selectively affect motor neurons, the cells that control voluntary musclesof the body.[3] Other motor neuron diseases include primary lateral sclerosis(PLS), progressive muscular atrophy(PMA), progressive bulbar palsy, pseudobulbar palsy, and monomelic amyotrophy(MMA).
Progressive bulbar palsy (PBP) is a medical condition. It belongs to a group of disorders known as motor neuron diseases. [ 1 ] PBP is a disease that attacks the nerves supplying the bulbar muscles. These disorders are characterized by the degeneration of motor neurons in the cerebral cortex, spinal cord, brain stem, and pyramidal tracts.
Weakness can be symmetric or asymmetric, and it can occur in body parts that are distal, proximal, or both. According to Statland et al., there are three main weakness patterns that are seen in motor neuron diseases, which are: [6] [9] Asymmetric distal weakness without sensory loss (e.g. ALS, PLS, PMA, MMA)
A fasciculation, or muscle twitch, is a spontaneous, involuntary muscle contraction and relaxation, involving fine muscle fibers. [1] They are common, with as many as 70% of people experiencing them. [1] They can be benign, or associated with more serious conditions. [1] When no cause or pathology is identified, they are diagnosed as benign ...
Multifocal motor neuropathy (MMN) is a progressively worsening condition where muscles in the extremities gradually weaken. The disorder, a pure motor neuropathy syndrome, is sometimes mistaken for amyotrophic lateral sclerosis (ALS) because of the similarity in the clinical picture, especially if muscle fasciculations are present.
There are more than 25 genes known to be associated with amyotrophic lateral sclerosis (ALS) as of June 2018, [ 1 ] which collectively account for about 70% of cases of familial ALS (fALS) and 10% of cases of sporadic ALS (sALS). [ 2 ] About 5–10% of cases of ALS are directly inherited. [ 3 ] Overall, first-degree relatives of an individual ...
ALSFRS-R includes 12 questions that can have a score of 0 to 4. A score of 0 on a question would indicate no function while a score of 4 would indicate full function. [4][5] This scale has been useful for doctors in diagnosing patients, measuring disease progression and also for researchers when selecting patients for a study and measuring the ...
Lytico-bodig (also Lytigo-bodig[1]) disease, Guam disease, or amyotrophic lateral sclerosis-parkinsonism-dementia (ALS-PDC) [2] is a neurodegenerative disease of uncertain etiology endemic to the Chamorro people of the island of Guam in Micronesia. Lytigo and bodig are Chamorro language words for two different manifestations of the same condition.
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