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Tetracyclic antidepressants (TeCAs) are a class of antidepressants that were first introduced in the 1970s. They are named after their tetracyclic chemical structure , containing four rings of atoms , and are closely related to the tricyclic antidepressants (TCAs), which contain three rings of atoms.
This is a complete list of clinically approved prescription antidepressants throughout the world, as well as clinically approved prescription drugs used to augment antidepressants or mood stabilizers, by pharmacological and/or structural classification.
Notes: (1) Opioids and amphetamines largely ceased being used by the 1950s with the introduction of modern antidepressants. (2) Some antidepressants can also have alternative classifications, such as mirtazapine being a "noradrenergic and specific serotonergic antidepressant" (NaSSA) or moclobemide being a "reversible inhibitor of monoamine ...
Mirtazapine, a tetracyclic antidepressant. Tetracyclics are cyclic chemical compounds that contain four fused rings of atoms, for example, Tröger's base . Some tricyclic compounds having three fused and one tethered ring (connected to main nucleus by a single bond) can also classified as tetracyclic, for example, ciclazindol .
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Mirtazapine, sold under the brand name Remeron among others, is an atypical tetracyclic antidepressant, and as such is used primarily to treat depression. [11] [12] Its effects may take up to four weeks but can also manifest as early as one to two weeks. [12] [13] It is often used in cases of depression complicated by anxiety or insomnia.
Mianserin is a tetracyclic piperazinoazepine. Mirtazapine was developed by the same team of organic chemists and differs via addition of a nitrogen atom in one of the rings. [ 43 ] [ 44 ] ( S )-(+)-Mianserin is approximately 200–300 times more active than its enantiomer ( R )-(−)-mianserin; hence, the activity of mianserin lies in the ( S ...