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B1 cells are a sub-class of B cell lymphocytes that are involved in the humoral immune response.They are not part of the adaptive immune system, as they have no memory, but otherwise, B1 cells perform many of the same roles as other B cells: making antibodies against antigens and acting as antigen-presenting cells.
A true homologue of mouse B-1 cells has not been discovered in humans, though various cell populations similar to B-1 cells have been described. [29] Regulatory B (Breg) cell An immunosuppressive B cell type that stops the expansion of pathogenic, pro-inflammatory lymphocytes through the secretion of IL-10, IL-35, and TGF-β. [31]
The MZ B cells within this region typically express low-affinity polyreactive B-cell receptors (BCR), high levels of IgM, Toll-like receptors (TLRs), CD21, CD1, CD9, CD27 with low to negligible levels of secreted-IgD, CD23, CD5, and CD11b that help to distinguish them phenotypically from follicular (FO) B cells and B1 B cells. [2] [3]
Stem cell donations save lives—and they are often a selfless act to help a stranger. But one case involving a Chicago man with leukemia shows it can help the donor too—in profound ways.
Regulatory B cells (Bregs or B reg cells) represent a small population of B cells that participates in immunomodulation and in the suppression of immune responses. The population of Bregs can be further separated into different human or murine subsets such as B10 cells, marginal zone B cells, Br1 cells, GrB + B cells, CD9 + B cells, and even some plasmablasts or plasma cells.
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5364 235611 Ensembl ENSG00000164050 ENSMUSG00000053646 UniProt O43157 Q8CJH3 RefSeq (mRNA) NM_001130082 NM_002673 NM_172775 RefSeq (protein) NP_001123554 NP_002664 NP_766363 Location (UCSC) Chr 3: 48.4 – 48.43 Mb Chr 9: 108.92 – 108.95 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Plexin B1 is a protein of the plexin family that in humans is encoded by the PLXNB1 gene. Function ...
1 B1 cell group. 2 B2 cell group. 3 B3 cell group. 4 B4 cell group. 5 B5 cell group. 6 B6 cell group. 7 B7 cell group. 8 B8 cell group. 9 B9 cell group. 10 References ...