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  2. Coagulation - Wikipedia

    en.wikipedia.org/wiki/Coagulation

    Coagulation cascade: It is a series of enzymatic reactions that lead to the formation of a stable blood clot. The endothelial cells release substances like tissue factor, which triggers the extrinsic pathway of the coagulation cascade. This is called as "secondary hemostasis". [20]

  3. Tissue factor - Wikipedia

    en.wikipedia.org/wiki/Tissue_factor

    The coagulation cascade. Tissue factor (TF) is the cell surface receptor for the serine protease factor VIIa. The best known function of tissue factor is its role in blood coagulation. The complex of TF with factor VIIa catalyzes the conversion of the inactive protease factor X into the active protease factor Xa.

  4. Factor XII - Wikipedia

    en.wikipedia.org/wiki/Factor_XII

    The coagulation cascade. Factor XII (FXII, Hageman factor) is a plasma glycoprotein of approximately 90 kDa and is part of the coagulation cascade. It activates factor XI and prekallikrein in vitro. FXII is activated to FXIIa by negatively charged surfaces such as glass, initiating the intrinsic pathway. [12]

  5. Contact activation system - Wikipedia

    en.wikipedia.org/wiki/Contact_activation_system

    Although the contact system can activate FXI and the subsequent clotting cascade, and it is routinely observed to activate coagulation in the presence of medical devices, [16] the actual role of the contact system in normal physiological coagulation remains contentious. This is primarily due to the fact that deficiencies in the contact system ...

  6. Hemostasis - Wikipedia

    en.wikipedia.org/wiki/Hemostasis

    Coagulation, the changing of blood from a liquid to a gel which forms the fibrin clots, is essential to hemostasis. Intact blood vessels moderate blood's tendency to form clots . The endothelial cells of intact vessels prevent blood clotting with a heparin-like molecule and thrombomodulin , and prevent platelet aggregation with nitric oxide and ...

  7. Coagulation testing - Wikipedia

    en.wikipedia.org/wiki/Coagulation_testing

    Global tests, also known as global coagulation assays (GCAs), [1] characterize the results of work of the whole clotting cascade. They suit to diagnose the general state of the blood coagulation system and the intensity of pathologies, and to simultaneously record all attendant influences.

  8. Biochemical cascade - Wikipedia

    en.wikipedia.org/wiki/Biochemical_cascade

    An example would be the coagulation cascade of secondary hemostasis which leads to fibrin formation, and thus, the initiation of blood coagulation. Another example, sonic hedgehog signaling pathway, is one of the key regulators of embryonic development and is present in all bilaterians. [2]

  9. Discovery and development of direct thrombin inhibitors

    en.wikipedia.org/wiki/Discovery_and_development...

    Coagulation cascade. When a blood vessel ruptures or gets injured, factor VII comes into contact with tissue factors which starts a process called the blood coagulation cascade. Its purpose is to stop bleeding and repair tissue damage. When this process is too active due to various problems the risk of blood clots or embolisms increases.

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