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Fursultiamine (INN; chemical name thiamine tetrahydrofurfuryl disulfide or TTFD; brand names Adventan, Alinamin-F, Benlipoid, Bevitol Lipophil, Judolor, Lipothiamine) is a medication and vitamin used to treat thiamine deficiency. Chemically, it is a disulfide derivative of thiamine and is similar in structure to allithiamine. [1]
Prosultiamine (INN; also known as thiamine propyl disulfide or TPD; brand name Jubedel,) is a disulfide thiamine derivative discovered in garlic in Japan in the 1950s, and is similar to allithiamine. It was developed as a treatment for vitamin B 1 deficiency .
Within the field of biochemistry, 4-amino-5-hydroxymethyl-2-methylpyrimidine (HMP) also known as toxopyrimidine together with its mono phosphate (HMP-P) and pyrophosphate (HMP-PP) esters are biogenetic precursors to the important biochemical cofactor thiamine pyrophosphate (TPP), a derivative of thiamine (vitamin B 1).
The typical composition of a banana bag is 1 liter of normal saline (sodium chloride 0.9%) with: [2] Thiamine 100 mg; Folic acid 1 mg; Multivitamin for infusion (MVI), 1 ampule; Magnesium sulfate 3 g; The solution is typically infused over four to eight hours or as per physician's orders.
Thiamine pyrophosphate (TPP or ThPP), or thiamine diphosphate (ThDP), or cocarboxylase [1] is a thiamine (vitamin B 1) derivative which is produced by the enzyme thiamine diphosphokinase. Thiamine pyrophosphate is a cofactor that is present in all living systems, in which it catalyzes several biochemical reactions.
Thiamine, also known as thiamin and vitamin B 1, is a vitamin – an essential micronutrient for humans and animals. [1] [3] [4] It is found in food and commercially synthesized to be a dietary supplement or medication. [1] Phosphorylated forms of thiamine are required for some metabolic reactions, including the breakdown of glucose and amino ...
Condensation of ethoxymethylenemalononitrile (1) with acetamidine (2) affords the substituted pyrimidine (4). The reaction may well involve conjugate addition of the amidine nitrogen to the malononitrile followed by loss of ethoxide ( 3 ); addition of the remaining amidine nitrogen to one of the nitriles will then lead to the pyrimidine ( 4 ).
Thiaminase is an enzyme that metabolizes or breaks down thiamine into pyrimidine and thiazole. It is an antinutrient when consumed. The old name was "aneurinase". [1] There are two types with different Enzyme Commission numbers: [2] Thiamine pyridinylase, Thiaminase I (EC 2.5.1.2, InterPro: IPR030901)