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Premalignant lesions are morphologically atypical tissue which appear abnormal when viewed under the microscope, and which are more likely to progress to cancer than normal tissue. [7] Precancerous conditions and lesions affect a variety of organ systems, including the skin, oral cavity, stomach, colon, lung, and hematological system.
[4] [5] The term "pre-cancer" has also been used. These abnormal cells grow in their normal place, thus in situ ( Latin for 'in its place'). For example, carcinoma in situ of the skin, also called Bowen's disease , is the accumulation of dysplastic epidermal cells within the epidermis only, that has failed to penetrate into the deeper dermis.
Ductal carcinoma in situ (DCIS), also known as intraductal carcinoma, is a pre-cancerous or non-invasive cancerous lesion of the breast. [1] [2] DCIS is classified as Stage 0. [3] It rarely produces symptoms or a breast lump that can be felt, typically being detected through screening mammography.
A cancerous tumor (or "solid tumor" in the jargon of oncologists to differentiate them from hematological malignancies) is an organ consisting of two tissues: in the center the cancerous tumor proper and around the ExtraCellular Matrix (ECM), sometimes called stroma, chorion or connective tissue. The concept of connective tissue is interesting ...
Some adenomas grow from epithelial tissue in nonglandular areas but express glandular tissue structure (as can happen in familial polyposis coli). Although adenomas are benign , they should be treated as pre-cancerous.
In one of the modern histopathological senses of the term, dysplasia is sometimes differentiated from other categories of tissue change including hyperplasia, metaplasia, and neoplasia, and dysplasias are thus generally not cancerous. An exception is that the myelodysplasias include a range of benign, precancerous, and cancerous forms. Various ...
Actinic keratosis (AK), sometimes called solar keratosis or senile keratosis, [1] [2] is a pre-cancerous [3] area of thick, scaly, or crusty skin. [4] [5] Actinic keratosis is a disorder of epidermal keratinocytes that is induced by ultraviolet (UV) light exposure ().
It is a precancerous lesion, a tissue alteration in which cancer is more likely to develop. [4] The chance of cancer formation depends on the type, with between 3–15% of localized leukoplakia and 70–100% of proliferative leukoplakia developing into squamous cell carcinoma. [4]