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Myb proto-oncogene protein is a member of the MYB (myeloblastosis) family of transcription factors. The protein contains three domains, an N-terminal DNA-binding domain, a central transcriptional activation domain and a C-terminal domain involved in transcriptional repression. It may play a role in cell cycle regulation.
The protein motif CCA1 uses to bind to its target DNA sequences is its Myb-like domain. CCA1 only has one Myb domain, whereas other plant and mammalian proteins could have multiple Myb domains. [3] The presence of only one Myb domain in CCA1 shows its importance influence in the circadian clock. LUX is also an important Myb transcription factor ...
Structure- and sequence-based prediction of DNA-binding sites in DNA-binding proteins can be performed on several web servers listed below. DISIS predicts DNA binding sites directly from the amino acid sequence and hence is applicable for all known proteins. It is based on the chemical-physical properties of the residue and its environment ...
4605 17865 Ensembl ENSG00000101057 ENSMUSG00000017861 UniProt P10244 P48972 RefSeq (mRNA) NM_002466 NM_001278610 NM_008652 RefSeq (protein) NP_001265539 NP_002457 NP_032678 Location (UCSC) Chr 20: 43.67 – 43.72 Mb Chr 2: 162.9 – 162.93 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Myb-related protein B is a protein that in humans is encoded by the MYBL2 gene. Function The ...
The Myb domain (InterPro: IPR017930) acts by binding to double-stranded telomeric DNA. This region gets its name from a viral protein called Myb derived from the avian myeloblastosis virus. Specifically, the sequence that this Myb domain targets on the DNA is (GGTTAG/CCAATC)n.
DNA-binding proteins are proteins that have DNA-binding domains and thus have a specific or general affinity for single- or double-stranded DNA. [ 3 ] [ 4 ] [ 5 ] Sequence-specific DNA-binding proteins generally interact with the major groove of B-DNA , because it exposes more functional groups that identify a base pair .
17864 Ensembl ENSG00000185697 ENSMUSG00000025912 UniProt P10243 P51960 RefSeq (mRNA) NM_001080416 NM_001144755 NM_001294282 NM_001290397 NM_008651 RefSeq (protein) NP_001073885 NP_001138227 NP_001281211 NP_001277326 NP_032677 Location (UCSC) Chr 8: 66.56 – 66.61 Mb Chr 1: 9.74 – 9.77 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse MYB proto-oncogene like 1 is a protein that in ...
A DNA-binding domain (DBD) is an independently folded protein domain that contains at least one structural motif that recognizes double- or single-stranded DNA. A DBD can recognize a specific DNA sequence (a recognition sequence ) or have a general affinity to DNA. [ 1 ]