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This is a list of 5α-reductase inhibitors (5α-RIs), drugs which inhibit one or more isoforms of the enzyme 5α-reductase.This enzyme is responsible for the conversion of the androgen hormone testosterone into the more potent dihydrotestosterone (DHT) and is essential for the production of neurosteroids like allopregnanolone, tetrahydrodeoxycorticosterone (THDOC), and 3α-androstanediol from ...
The first effective treatment for benign prostatic hyperplasia (BPH) was a non-selective alpha blocker phenoxybenzamine which was irreversible. Dibenzyline was the first brand name marketed. Today phenoxybenzamine is not the first choice due to many side effects like lowering blood pressure. [2]
Dutasteride (brand name Avodart) inhibits all three 5α-reductase isoenzymes and can decrease DHT levels by 95%. [9] [10] It can also reduce DHT levels in the prostate by 97 to 99% in men with prostate cancer. [11] [12] Epristeride (brand names Aipuliete, Chuanliu) is marketed in China for the treatment of benign prostatic hyperplasia.
There is only one compelling indication for alpha blockers, which is for benign prostatic hyperplasia. [33] Patients who need alpha blockers for BPH, but have a history of hypotension or postural heart failure , should use these drugs with caution, as it may result in an even greater decrease in blood pressure or make heart failure even worse.
Tadalafil is a widely used medication, mostly prescribed to treat ED and sometimes to treat the symptoms of benign prostatic hyperplasia (BPH) as well as pulmonary arterial hypertension (under the ...
Benign prostatic hyperplasia (BPH), also called prostate enlargement, is a noncancerous increase in size of the prostate gland. [1] Symptoms may include frequent urination , trouble starting to urinate, weak stream, inability to urinate , or loss of bladder control . [ 1 ]
Research shows that taking 5 milligrams (mg) of finasteride a day for benign prostatic hyperplasia (BPH) — an enlarged prostate — can lead to a 15 to 25 percent increase in testosterone levels.
Tamsulosin, sold under the brand names including Flomax and Contiflo, is a medication used to treat symptomatic benign prostatic hyperplasia (BPH) and chronic prostatitis and to help with the passage of kidney stones. [6] [7] [8] The evidence for benefit with a kidney stone is better when the stone is larger. [8] Tamsulosin is taken by mouth. [6]
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