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The ingestion of neem oil is potentially toxic and can cause metabolic acidosis, seizures, kidney failure, encephalopathy and severe brain ischemia in infants and young children. [2] [8] [9] Neem oil should not be consumed alone without any other solutions, particularly by pregnant women, women trying to conceive or children. [2]
Some laboratory and field studies have found neem extracts to be compatible with biological control. Because pure neem oil contains other insecticidal and fungicidal compounds in addition to azadirachtin, it is generally mixed at a rate of 1 US fluid ounce per US gallon (7.8 mL/L) of water when used as a pesticide.
The fruit is a smooth , olive-like drupe which varies in shape from elongate oval to nearly roundish, and when ripe is 14–28 mm (1 ⁄ 2 – 1 + 1 ⁄ 8 in) by 10–15 mm (3 ⁄ 8 – 5 ⁄ 8 in). The fruit skin (exocarp) is thin and the bitter-sweet pulp (mesocarp) is yellowish-white and very fibrous.
In the USA 13 are registered for use, in the EU 6. In Korea, where it is easier to register botanical pesticides, 38 are used. Most used are neem oil, chenopodium, pyrethrins, and azadirachtin. [49] Many botanical insecticides used in past decades (e.g. rotenone, nicotine, ryanodine) have been banned because of their toxicity. [49]
Azadirachta is a genus of two species of trees in the mahogany family Meliaceae. [2] Numerous species have been proposed for the genus but only two are currently recognized, Azadirachta excelsa and the economically important tree Azadirachta indica , the neem tree, from which neem oil is extracted.
Canada's drug regulations are measures of the Food and Drug Act and the Controlled Drugs and Substances Act.In relation to controlled and restricted drug products, the Controlled Drugs and Substances Act establishes eight schedules of drugs and new penalties for the possession, trafficking, exportation and production of controlled substances as defined by the Governor-in-Council.
It was also used internally in the past, for stomach and other ailments, but its toxicity has led a number of other countries, including Canada, Brazil, Australia, and the United Kingdom, to severely restrict or ban the use of comfrey. [151] Syzygium aromaticum: Clove: The plant is used for upset stomach and as an expectorant, among other purposes.
The committee was made up of representatives from each of the provinces and territories and the federal departments Agriculture Canada, Environment Canada, and Health and Welfare Canada. [3] The PMRA was created on April 1, 1995, as part of an ongoing government effort to reform the pesticide regulatory regime in Canada.
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