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Most Pax genes contain a homeobox and a paired domain that also binds DNA to increase binding specificity, though some Pax genes have lost all or part of the homeobox sequence. [46] Pax genes function in embryo segmentation , nervous system development, generation of the frontal eye fields , skeletal development, and formation of face structures.
The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters , HOXA, HOXB, HOXC and HOXD, located on different chromosomes , consisting of 9 to 11 genes arranged in tandem.
3200 15400 Ensembl ENSG00000105997 ENSMUSG00000079560 UniProt O43365 P02831 RefSeq (mRNA) NM_030661 NM_153631 NM_153632 NM_010452 RefSeq (protein) NP_109377 NP_705895 NP_034582 Location (UCSC) Chr 7: 27.11 – 27.15 Mb Chr 6: 52.15 – 52.19 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Homeobox protein Hox-A3 is a protein that in humans is encoded by the HOXA3 gene. Function In ...
3206 15395 Ensembl ENSG00000253293 ENSMUSG00000000938 UniProt P31260 P31310 RefSeq (mRNA) NM_018951 NM_153715 NM_001122950 NM_008263 RefSeq (protein) NP_061824 NP_001116422 NP_032289 Location (UCSC) Chr 7: 27.17 – 27.18 Mb Chr 6: 52.21 – 52.22 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Homeobox protein Hox-A10 is a protein that in humans is encoded by the HOXA10 gene ...
Homeobox containing 1, also known as homeobox telomere-binding protein 1 (HOT1), is a protein that in humans is encoded by the HMBOX1 gene. [5] HMBOX1 directly binds to the double-stranded repeat sequence of telomeres .
Homeobox protein goosecoid (GSC) is a homeobox protein that is encoded in humans by the GSC gene. Like other homeobox proteins, goosecoid functions as a transcription factor involved in morphogenesis. In Xenopus, GSC is thought to play a crucial role in the phenomenon of the Spemann-Mangold organizer. [5]
Homeobox protein Meis2 is a protein that in humans is encoded by the MEIS2 gene. [ 5 ] [ 6 ] This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins.
Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC4, is one of several homeobox HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon.