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Salicylate toxicity also causes an uncoupling of oxidative phosphorylation and a decrease in citric acid cycle activity in the mitochondria. [9] This decrease in aerobic production of adenosine triphosphate (ATP) is accompanied by an increase in anaerobic production of ATP through glycolysis which leads to glycogen depletion and hypoglycemia. [9]
This unique chemotherapeutic agent causes oxidative damage to the nucleotides and leads to single- and double-stranded breaks in DNA. Excess breaks in DNA eventually causes cell death. [ 9 ] Few case reports have identified the development of ototoxicity in some elderly patients who were administered with bleomycin. [ 17 ]
Ototoxicity of gentamicin can be exploited to treat some individuals with Ménière's disease by destroying the inner ear, which stops the vertigo attacks but causes permanent deafness. [19] Due to the effects on mitochondria, certain inherited mitochondrial disorders result in increased sensitivity to the toxic effects of aminoglycosides.
Tinnitus Today [8] is a magazine focused on the tinnitus patient community, tinnitus research, and the healthcare providers who see tinnitus patients. The publication provides inspiring tinnitus patient stories, tinnitus management strategies, tinnitus treatment information, tinnitus help tools, and news and updates on innovative tinnitus research.
The best-supported treatment for tinnitus is cognitive behavioral therapy (CBT). [5] [84] [102] It decreases the stress those with tinnitus feel. [103] This appears to be independent of any effect on depression or anxiety. [102] Acceptance and commitment therapy (ACT) also shows promise in the treatment of tinnitus. [104] Relaxation techniques ...
Eustachian tube dysfunction can be caused by a number of factors. Some common causes include the flu, allergies, a cold, and sinus infections. [6] In patients with chronic ear disease such as cholesteatoma and chronic discharge, studies showed that they have obstructive pathology at the ear side of the Eustachian tube.
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Tinnitus retraining therapy, a treatment originally used to treat tinnitus, uses broadband noise to treat hyperacusis. Pink noise can also be used to treat hyperacusis. By listening to broadband noise at soft levels for a disciplined period of time each day, some patients can rebuild (i.e., re-establish) their tolerances to sound.
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