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  2. Drug tolerance - Wikipedia

    en.wikipedia.org/wiki/Drug_tolerance

    Drug tolerance or drug insensitivity is a pharmacological concept describing subjects' reduced reaction to a drug following its repeated use. Increasing its dosage may re-amplify the drug's effects; however, this may accelerate tolerance, further reducing the drug's effects.

  3. Tolerability - Wikipedia

    en.wikipedia.org/wiki/Tolerability

    Tolerability refers to the degree to which overt adverse effects of a drug can be tolerated by a patient. [1] Tolerability of a particular drug can be discussed in a general sense, or it can be a quantifiable measurement as part of a clinical study.

  4. Drug intolerance - Wikipedia

    en.wikipedia.org/wiki/Drug_intolerance

    For example, a patient could possess a genetic defect in a drug metabolizing enzyme in the cytochrome P450 superfamily. While most individuals will possess the effective metabolizing machinery, a person with a defect will have a difficult time trying to clear the drug from their system. Thus, the drug will accumulate within the blood to higher ...

  5. Alcohol withdrawal syndrome - Wikipedia

    en.wikipedia.org/wiki/Alcohol_withdrawal_syndrome

    More severe symptoms may include seizures, and delirium tremens (DTs); which can be fatal in untreated patients. [1] Symptoms start at around 6 hours after the last drink. [2] Peak incidence of seizures occurs at 24-36 hours [5] and peak incidence of delirium tremens is at 48-72 hours. [6] Alcohol withdrawal may occur in those who are alcohol ...

  6. Drug withdrawal - Wikipedia

    en.wikipedia.org/wiki/Drug_withdrawal

    Drug withdrawal, drug withdrawal syndrome, or substance withdrawal syndrome [1] is the group of symptoms that occur upon the abrupt discontinuation or decrease in the intake of pharmaceutical or recreational drugs. In order for the symptoms of withdrawal to occur, one must have first developed a form of drug dependence.

  7. SPOILER ALERT: This article contains major plot details from the finale of Edward Berger’s “Conclave.” Megyn Kelly took to X to criticize Edward Berger’s “Conclave” as a “disgusting ...

  8. Former 'Jerry Springer' producers recall how they manipulated ...

    www.aol.com/news/former-jerry-springer-producers...

    The new Netflix docuseries, "Jerry Springer: Fights, Camera, Action," explores the controversial popularity of "The Jerry Springer Show" in the '90s.

  9. Tachyphylaxis - Wikipedia

    en.wikipedia.org/wiki/Tachyphylaxis

    Tachyphylaxis (Greek ταχύς, tachys, "rapid", and φύλαξις, phylaxis, "protection") is a medical term describing an acute, sudden decrease in response to a drug after its administration (i.e., a rapid and short-term onset of drug tolerance). [1] It can occur after an initial dose or after a series of small doses.