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2. PDE5 inhibitor - Wikipedia

   en.wikipedia.org/wiki/PDE5_inhibitor

   Chemical structure of sildenafil (Viagra), the prototypical PDE5 inhibitor. A phosphodiesterase type 5 inhibitor (PDE5 inhibitor) is a vasodilating drug that works by blocking the degradative action of cGMP-specific phosphodiesterase type 5 (PDE5) on cyclic GMP in the smooth muscle cells lining the blood vessels supplying various tissues.

3. Phosphodiesterase inhibitor - Wikipedia

   en.wikipedia.org/wiki/Phosphodiesterase_inhibitor

   Phosphodiesterase-5. A phosphodiesterase inhibitor is a drug that blocks one or more of the five subtypes of the enzyme phosphodiesterase (PDE), thereby preventing the inactivation of the intracellular second messengers, cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) by the respective PDE subtype(s).

4. List of phosphodiesterase inhibitors - Wikipedia

   en.wikipedia.org/wiki/List_of_phosphodiesterase...

   This page was last edited on 9 February 2024, at 00:17 (UTC).; Text is available under the Creative Commons Attribution-ShareAlike 4.0 License; additional terms may apply.

5. Got Headaches from Viagra or Cialis? Here's Why & How to Treat It

   www.aol.com/got-headaches-viagra-cialis-heres...

   For example, some phosphodiesterase inhibitors are used to treat a form of high blood pressure in the arteries of your lungs called pulmonary hypertension. These changes in blood flow may play a ...

6. 4 Common ED Pills: Weighing the Pros & Cons of Each - AOL

   www.aol.com/4-common-ed-pills-weighing-141800609...

   All of these meds belong to a class of drugs called phosphodiesterase type 5 inhibitors, ... in a day with a break between rounds one and two — for example, once in the afternoon and once at ...

7. Tadalafil: Your Ultimate Guide to Dosages, Side Effects & More

   www.aol.com/tadalafil-ultimate-guide-dosages...

   Tadalafil works by inhibiting the effects of cGMP-specific phosphodiesterase type 5 (or PDE5) — an enzyme found in the smooth muscle cells of blood vessels. ... drug is a PDE5 inhibitor, meaning ...

8. Discovery and development of phosphodiesterase 5 inhibitors

   en.wikipedia.org/wiki/Discovery_and_development...

   Phosphodiesterase 5 is widely expressed in several tissues in the body for example brain, lung, kidney, urinary bladder, smooth muscle and platelets. [1] It is possible to prevent cGMP hydrolysis by inhibiting PDE5 and therefore treat diseases associated with low cGMP levels, because of this, PDE5 is an ideal target for the development of ...

9. What Does Viagra Actually Do to Your "Intimate" Experience? - AOL

   www.aol.com/does-viagra-actually-intimate...

   For example, a common sign of low testosterone is a weaker-than-normal drive. ... BUT be careful — like tadalafil, vardenafil, and other phosphodiesterase type 5 inhibitors, Viagra should be ...