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A deuterated drug is a small molecule medicinal product in which one or more of the hydrogen atoms in the drug molecule have been replaced by its heavier stable isotope deuterium. Because of the kinetic isotope effect , deuterium-containing drugs may have significantly lower rates of metabolism , and hence a longer half-life .
The exchange reaction can be followed using a variety of methods (see Detection). Since this exchange is an equilibrium reaction, the molar amount of deuterium should be high compared to the exchangeable protons of the substrate. For instance, deuterium is added to a protein in H 2 O by diluting the H 2 O solution with D 2 O (e.g. tenfold ...
[1] [6] [3] However, CYB004, due to its deuteration, is more resistant to metabolism than DMT and shows a longer elimination half-life (by 2.5- to 2.9-fold) and slower clearance (by 38 to 55%) in animals. [3] The brain to plasma ratio of CYB004 was also increased (by 30%) relative to DMT, indicating slightly greater central permeability as well ...
This is a list of notable medical and scientific journals that publish articles in pharmacology and the pharmaceutical sciences This is a dynamic list and may never be able to satisfy particular standards for completeness.
This list is organized by type of agent, although the subsections are not necessarily definitive and are subject to revision. Each drug is listed once (at present), though it might fall in more than one subsection. A full alphabetical listing is included after the categorical listing.
Adolescent Health, Medicine and Therapeutics; Advanced Health Care Technologies † Advances and Applications in Bioinformatics and Chemistry; Advances in Genomics and Genetics † Advances in Medical Education and Practice; Ambulatory Anesthesia † Antibody Technology Journal † Application of Clinical Genetics
Over a hundred of the 224 drugs mentioned in the Huangdi Neijing – an early Chinese medical text – are herbs. [11] Herbs also commonly featured in the medicine of ancient India, where the principal treatment for diseases was diet. [12] A sample of raw opium. Opioids are among the world's oldest known drugs.
Deudextromethorphan/quinidine (d-DXM/Q; developmental code names AVP-786, CTP-786) is a combination of deudextromethorphan (d-DXM; deuterated (d6) dextromethorphan (DXM)) and quinidine (Q) which is under development by Avanir Pharmaceuticals for the treatment of a variety of neurological and psychiatric indications.