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Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component that serves as a template for the telomere repeat.
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The role of telomeres and telomerase in cell aging and cancer was established by scientists at biotechnology company Geron with the cloning of the RNA and catalytic components of human telomerase [9] and the development of a polymerase chain reaction (PCR) based assay for telomerase activity called the TRAP assay, which surveys telomerase ...
These complex structures have been shown help to modulate telomere length through inhibition telomerase's ability to add tandem TTAGGG repeats, specifically in cells with long telomeres. This inhibitive effect seems to function in a telomere length-dependent manner; [ 3 ] that is, TERRA levels inversely correlate with increased activity of ...
Telomerase RNA component, also known as TR, TER or TERC, is an ncRNA found in eukaryotes that is a component of telomerase, the enzyme used to extend telomeres. [ 3 ] [ 4 ] TERC serves as a template for telomere replication ( reverse transcription ) by telomerase.
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The steps to add new access numbers may differ depending on the version of AOL Dialer installed on your computer. If you're using ACS, you'll want to download the latest version of AOL Dialer here. Connect an access number to AOL Dialer. 1. Click Connection Settings from the mail AOL Dialer page and follow the prompts. 2.
Telomeres are shortened with every duplication of DNA, and must be lengthened again. He studies telomerase , the enzyme that copies the telomeric sequences and lengthens them. [ 8 ] The active site protein subunits of telomerase comprise a new class of reverse transcriptases , enzymes previously thought to be restricted to viruses and ...
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