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The signs and symptoms of ankylosing spondylitis often appear gradually, with peak onset between 20 and 30 years of age. [11] Initial symptoms are usually a chronic dull pain in the lower back or gluteal region combined with stiffness of the lower back. [12] Individuals often experience pain and stiffness that awakens them in the early morning ...
Symptoms typically begin in early adulthood, with back pain, stiffness in the lower back, neck pain, and fatigue being common ones. Steff received an official diagnosis of ankylosing spondylitis ...
Acantholysis is the loss of intercellular connections, such as desmosomes, resulting in loss of cohesion between keratinocytes, [1] seen in diseases such as pemphigus vulgaris. [2] It is absent in bullous pemphigoid , making it useful for differential diagnosis .
Low back pain is not a specific disease but rather a complaint that may be caused by a large number of underlying problems of varying levels of seriousness. [30] The majority of low back pain does not have a clear cause [1] but is believed to be the result of non-serious muscle or skeletal issues such as sprains or strains. [31]
[3] [4] Chronic pain is considered a syndrome because of the associated symptoms that develop in those experiencing this disorder. [5] Chronic pain affects approximately 20% of people worldwide and accounts for 15–20% of visits to a physician. [3] Pain can be categorized according to its location, cause, or the anatomical system which it affects.
Over-diagnosis and attention on herniated discs has led to the SI joint becoming an underappreciated pain generator in an estimated 15% to 25% of patients with axial low back pain. [1] [8] [3] [5] [6] [7] The ligaments in the sacroiliac are among the strongest in the body and are not suspected by many clinicians to be susceptible to spraining ...
In all subtypes of spondyloarthritis, inflammatory back pain and/or asymmetrical arthritis, mainly affecting the lower limbs, are the most common symptoms. [9] Another characteristic is enthesitis, which is inflammation at the locations where ligaments, tendons, or joint capsules adhere to bone.
Histopathological image of dyshidrotic dermatitis, showing focal spongiotic change in the epidermis. Spongiosis is mainly intercellular [1] edema (abnormal accumulation of fluid) in the epidermis, [2] and is characteristic of eczematous dermatitis, manifested clinically by intraepidermal vesicles (fluid-containing spaces), "juicy" papules, and/or lichenification. [3]