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In enzymology, a 1-deoxy-d-xylulose-5-phosphate synthase (EC 2.2.1.7) is an enzyme in the non-mevalonate pathway that catalyzes the chemical reaction pyruvate + d -glyceraldehyde 3-phosphate ⇌ {\displaystyle \rightleftharpoons } 1-deoxy- d -xylulose 5-phosphate + CO 2
The enzyme involved in making 1-deoxy-d-xylulose 5-phosphate (DXP) is DXP synthase. [2] The mechanism follows a catalysis of decarboxylative condensation of pyruvate and d-glyceraldehyde 3-phosphate to produce DXP. [2] [3] In addition, the molecule is involved in making thiamine (vitamin B 1) and pyridoxol (vitamin B 6). [2]
D-Xylulose 5-phosphate (D-xylulose-5-P) is an intermediate in the pentose phosphate pathway. It is a ketose sugar formed from ribulose-5-phosphate by ribulose-5-phosphate epimerase. In the non-oxidative branch of the pentose phosphate pathway, xylulose-5-phosphate acts as a donor of two-carbon ketone groups in transketolase reactions.
This may also be called standard range. In contrast, optimal (health) range or therapeutic target is a reference range or limit that is based on concentrations or levels that are associated with optimal health or minimal risk of related complications and diseases. For most substances presented, the optimal levels are the ones normally found in ...
This pathway, called methyl-D-erythritol phosphate (MEP) or non-mevalonate pathway, is responsible for biosynthesis of isoprenoids—molecules required for cell survival in most pathogenic bacteria and hence will be helpful in most usually antibacterial resistant bacteria. [17]
Reference ranges for other molecules in CSF Substance Lower limit Upper limit Unit Corresponds to % of that in plasma Glucose: 50 [2] 80 [2] mg/dL ~60% [1] 2.2, [3] 2.8 [1] 3.9, [3] 4.4 [1] mmol/L Protein: 15 [1] [2] 40, [4] 45 [1] [2] mg/dL ~1% [1] Albumin: 7.8 [5] 40 [5] mg/dL: 0 [6] - 0.7% [6] - corresponding to an albumin (CSF/serum ...
Vitamin B 6 Drug class Pyridoxal 5'-phosphate, the metabolically active form of vitamin B 6 Class identifiers Use Vitamin B 6 deficiency ATC code A11H Biological target enzyme cofactor Clinical data Drugs.com International Drug Names External links MeSH D025101 Legal status In Wikidata Vitamin B 6 is one of the B vitamins, and is an essential nutrient for humans. The term essential nutrient ...
A phosphate concentration greater than 1.46 mmol/L (4.5 mg/dL) is indicative of hyperphosphatemia, though further tests may be needed to identify the underlying cause of the elevated phosphate levels. [5] It is considered significant when levels are greater than 1.6 mmol/L (5 mg/dL). [2]