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Interstitial keratitis (IK), also known as Immune Stromal Keratitis (ISK), is an eye disorder characterized by scarring of the cornea due to chronic inflammation of the corneal stroma . "Interstitial" refers to space between cells (i.e. the corneal stroma, which lies between the epithelium and the endothelium ).
The lumps appear to be randomly positioned on the cornea and they may appear and disappear over a period of time (with or without treatment). TSPK may affect one or both eyes. When both eyes are affected, the tiny lumps found on the cornea may differ in number between eyes. The severity of the symptoms often vary during the course of the ...
Corneal opacification is a term used when the human cornea loses its transparency. The term corneal opacity is used particularly for the loss of transparency of cornea due to scarring. Transparency of the cornea is dependent on the uniform diameter and the regular spacing and arrangement of the collagen fibrils within the stroma.
The corneal transplant surgeon trephines a lenticule of corneal tissue and then grafts the donor cornea to the existing eye tissue, usually using a combination of running and individual sutures. The cornea does not have a direct blood supply, so the donor tissue is not required to be blood type matched.
Usually, the condition is better after a week to 10 days without treatment. [3] Cold compresses and artificial tears may help. [2] Corneal scarring occurs in up to half of cases and the blurred vision may continue for a long time in some people. [2] The virus may remain in the eye for 2–3 years after recovering. [3]
The symptoms of phlyctenular keratoconjunctivitis are primarily treated with application of an appropriate corticosteroid eye drop, such as prednisolone acetate (Pred Forte) or loteprednol (Lotemax). Loteprednol is increasingly preferred due to its lower risk of elevating intraocular pressure .
Peripheral Ulcerative Keratitis (PUK) is a group of destructive inflammatory diseases involving the peripheral cornea in human eyes. [1] The symptoms of PUK include pain, redness of the eyeball, photophobia, and decreased vision accompanied by distinctive signs of crescent-shaped damage of the cornea.
Treatment options include contact lenses and intrastromal corneal ring segments for correcting refractive errors caused by irregular corneal surface, [7] [8] corneal collagen cross-linking to strengthen a weak and ectatic cornea, [9] or corneal transplant for advanced cases.