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Conjugated estrogens/medroxyprogesterone acetate (CEs/MPA), sold under the brand names Prempro and Premphase, is a combination product of conjugated equine estrogens (Premarin), an estrogen collected from horse urine, and medroxyprogesterone acetate (Provera), a progestogen, which is used in menopausal hormone therapy for the treatment of menopausal symptoms.
EC 50 Tooltip Half-maximal effective concentration (nM) a EC 50 Tooltip Half-maximal effective concentration (nM) b; Progesterone: 4.3: 0.9: 25 Medroxyprogesterone: 241: 47: 32 Medroxyprogesterone acetate: 1.2: 0.6: 0.15 Footnotes: a = Coactivator recruitment. b = Reporter cell line. Sources: [128]
Estradiol and norethisterone acetate (Combipatch) – 50 μg/24 hours / 0.14 mg/24 hours; 50 μg/24 hours / 0.25 mg/24 hours Combined with other medications [ edit ]
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25 μg/day b: 50 μg/day b: 100 μg/day b: Transdermal gel: Estradiol: 0.5 mg/day ... Wyeth also won five summary judgments on Prempro cases and had 15 cases ...
The duration of progestogen therapy should be at least 14 days per cycle to prevent endometrial disease. [52] Endometrial cancer has been grouped into two forms in the context of hormone replacement. Type 1 is the most common, can be associated with estrogen therapy, and is usually low grade.