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2. Is There a "Best Time" to Take Metformin? - AOL

   www.aol.com/best-time-metformin-115700262.html

   There’s a maximum daily dose, so it’s possible to take too much metformin. Metformin overdose can include the following symptoms: Abnormally fast or slow heartbeat

3. How Long Will It Take to Lose Weight on Metformin?

   www.aol.com/long-does-metformin-weight-loss...

   This dose may then increase by 500mg each week, up to a maximum of 2,000mg a day. A healthcare provider can help work out the best dose of metformin for weight loss for you. Look out for the ...

4. Metformin Can Help You Lose Weight Loss, But It Also Has ...

   www.aol.com/metformin-help-lose-weight-loss...

   2. Alleviates Hunger. Metformin improves how well your cells respond to insulin. This helps regulate your blood sugar levels and manage spikes in insulin that can trigger hunger and food cravings.

5. Therapeutic index - Wikipedia

   en.wikipedia.org/wiki/Therapeutic_index

   For many drugs, severe toxicities in humans occur at sublethal doses, which limit their maximum dose. A higher safety-based therapeutic index is preferable instead of a lower one; an individual would have to take a much higher dose of a drug to reach the lethal threshold than the dose taken to induce the therapeutic effect of the drug.

6. Metformin - Wikipedia

   en.wikipedia.org/wiki/Metformin

   High blood lactic acid level is a concern if the medication is used in overly large doses or prescribed in people with severe kidney problems. [23] [24] Metformin is a biguanide anti-hyperglycemic agent. [16]

7. Effective dose (pharmacology) - Wikipedia

   en.wikipedia.org/wiki/Effective_dose_(pharmacology)

   The median effective dose is the dose that produces a quantal effect (all or nothing) in 50% of the population that takes it (median referring to the 50% population base). [6] It is also sometimes abbreviated as the ED 50, meaning "effective dose for 50% of the population". The ED50 is commonly used as a measure of the reasonable expectancy of ...