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Fenfluramine as a single drug was first introduced in the 1970s, but was not popular because it only temporarily reduced weight. [1] A 1984 study found a weight loss of 7.5 kg on average in 24 weeks, as compared to 4.4 kg under placebo. [4]
amitriptyline – tricyclic antidepressant used to treat separation anxiety, excessive grooming dogs and cats; amlodipine – calcium channel blocker used to decrease blood pressure; amoxicillin – antibacterial; apomorphine – emetic (used to induce vomiting) artificial tears – lubricant eye drops used as a tear supplement
The pharmacokinetics of phentermine are dose-dependent. [ 6 ] [ 6 ] Peak concentrations of phentermine are reached 6 hours following oral administration of a dose of 15 mg. [ 6 ] The steady-state levels of phentermine with continuous administration have been found to be around 200 ng/mL in clinical studies. [ 6 ]
If less than 3% weight loss is seen after 3 months it is recommended the medication be stopped. [3] The weight loss is modest. [ 3 ] Effects on heart related health problems or death is unclear.
Fenfluramine is indicated for the treatment of seizures associated with Dravet syndrome and Lennox–Gastaut syndrome in people age two and older. [3] [7] [4]Dravet syndrome is a life-threatening, rare and chronic form of epilepsy. [7]
Side effects in dogs and cats include hypersalivation, diarrhea, loss of appetite, and vomiting. [12] [16] Eight percent of dogs taking maropitant at doses meant to prevent motion sickness vomited right after, likely due to the local effects maropitant had on the gastrointestinal tract. Small amounts of food beforehand can prevent such post ...
Chemically, it is a substituted phenethylamine and amphetamine and is closely related to phentermine and methamphetamine. [4] [9] [1] Mephentermine was first described and introduced for medical use by 1952. [10] It was discontinued in the United States between 2000 and 2004. [2] [7] The medication appears to remain available only in India.
[27] [26] The activity of chlorphentermine as an SSRA is in contrast to phentermine, which acts as a selective norepinephrine and dopamine releasing agent (NDRA). [26] [18] In animals, chlorphentermine robustly and dose-dependently increases serotonin levels in the brain. [23] [14] It also increases dopamine levels in the brain at high doses.
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