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They worked primarily by suppressing appetite, and had other beneficial effects such as increased alertness. Use of amphetamines increased over the subsequent decades, including Obetrol and culminating in the "rainbow diet pill" regime. [38] This was a combination of multiple pills, all thought to help with weight loss, taken throughout the day.
Phentermine is used for a short period of time to promote weight loss, if exercise and calorie reduction are not sufficient, and in addition to exercise and calorie reduction. [5] [11] Phentermine is approved for up to 12 weeks of use and most weight loss occurs in the first weeks. [11]
Phenmetrazine acts as a releasing agent of norepinephrine and dopamine with EC 50 values of 50.4 ± 5.4 nM and 131 ± 11 nM, respectively. [9] It has negligible efficacy as a releaser of serotonin, with an EC 50 value of only 7,765 ± 610 nM. [9] After an oral dose, about 70% of the drug is excreted from the body within 24 hours.
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This amounts to an additional weight loss of 4±2 kg over the course of 24 weeks. Adverse effects were less frequent with the combination regimen than with the other active (non-placebo) treatments. The authors felt that combining fenfluramine and phentermine capitalized on their pharmacodynamic differences, resulting in equivalent weight loss ...
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