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The most common side effects of these drugs that led to withdrawals were mental disturbances, cardiac side effects, and drug abuse or drug dependence. Deaths were associated with seven products. [83] Ephedra was removed from the US market in 2004 over concerns that it raises blood pressure and could lead to strokes and death. [84]
The effectiveness of orlistat in promoting weight loss is definite but modest. Pooled data from clinical trials suggest that people given orlistat in addition to lifestyle modifications, such as diet and exercise, lose about 2–3 kilograms (4–7 lb) more than those not taking the drug over the course of a year. [11]
The Mayo Clinic diet was created by weight management practitioners at the Mayo Clinic and was designed as a lifestyle change program to promote gradual and sustained weight loss, says Melissa ...
This amounts to an additional weight loss of 4±2 kg over the course of 24 weeks. Adverse effects were less frequent with the combination regimen than with the other active (non-placebo) treatments. The authors felt that combining fenfluramine and phentermine capitalized on their pharmacodynamic differences, resulting in equivalent weight loss ...
U.S. News & World Report ranked the Mayo Clinic Diet as 3.42 out of 5 for long-term weight loss. The program also has majority four- and five-star (out of five stars) reviews on Trustpilot.com.
However, weight loss is a much-talked-about side effect. Another drug, Wegovy, contains the same active ingredient (semaglutide), is made by the same company (Novo Nordisk) and is approved for ...
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