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Howard Green (September 10, 1925 – October 31, 2015) was an American scientist, and George Higginson Professor of Cell Biology at Harvard Medical School. He was the first to culture human cells in a laboratory setting for therapeutic use. He is one of the founding fathers of stem-cell research and regenerative medicine.
Wnt-1 was later discovered to be a key player in the stem cell self-renewal pathway. [8] She joined the biotech company SyStemix from 1989 to 1997, [9] where she co-discovered the human hematopoietic stem cell (hHSC) and played a leading role in the launch of the clinical research program for this cell. The purified hHSC was shown to be cancer ...
Working together, biologists James Till and Ernest McCulloch made contributions to stem cell research by demonstrating the existence of multipotent stem cells in 1961. They helped lay the foundation for modern stem cell biology and regenerative medicine through their work while studying the effects of radiation on the bone marrow of mice at the Ontario Cancer Institute in Toronto.
Astellas Institute for Regenerative Medicine is a subsidiary of Astellas Pharma located in Marlborough, Massachusetts, US, developing stem cell therapies with a focus on diseases that cause blindness. It was formed in 1994 as a company named Advanced Cell Technology, Incorporated (ACT), which was renamed to Ocata Therapeutics in November 2014. [3]
Stem-cell therapy uses stem cells to treat or prevent a disease or condition. [1] As of 2024, the only FDA-approved therapy using stem cells is hematopoietic stem cell transplantation. [2] [3] This usually takes the form of a bone marrow or peripheral blood stem cell transplantation, but the cells can also be derived from umbilical cord blood.
A woman has undergone a stem-cell therapy made from her own cells, to treat her type 1 diabetes. Researchers in China discovered the woman did not need to use insulin 75 days after the procedure ...
Cell replacement therapy with iPS cells is a possibility. Stem cells can replace diseased or lost cells in degenerative disorders and they are less prone to immune rejection. However, there is a danger that it may introduce mutations or other genomic abnormalities that render it unsuitable for cell therapy.
For over 90 years, hematopoietic stem cell transplantation (HSCT) has been used to treat people with conditions such as leukaemia and lymphoma; this is the only widely practiced form of stem-cell therapy. [94] [97] [98] As of 2016, the only established therapy using stem cells is hematopoietic stem cell transplantation. [99]