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Howard Green (September 10, 1925 – October 31, 2015) was an American scientist, and George Higginson Professor of Cell Biology at Harvard Medical School. He was the first to culture human cells in a laboratory setting for therapeutic use. He is one of the founding fathers of stem-cell research and regenerative medicine.
Stem-cell therapy uses stem cells to treat or prevent a disease or condition. [1] As of 2024, the only FDA-approved therapy using stem cells is hematopoietic stem cell transplantation. [2] [3] This usually takes the form of a bone marrow or peripheral blood stem cell transplantation, but the cells can also be derived from umbilical cord blood.
Working together, biologists James Till and Ernest McCulloch made contributions to stem cell research by demonstrating the existence of multipotent stem cells in 1961. They helped lay the foundation for modern stem cell biology and regenerative medicine through their work while studying the effects of radiation on the bone marrow of mice at the Ontario Cancer Institute in Toronto.
In 1998, Thomson's Lab was the first to report the successful isolation of human embryonic stem cells. On November 6, 1998, Science published this research in an article titled "Embryonic Stem Cell Lines Derived from Human Blastocysts", results which Science later featured in its “Scientific Breakthrough of the Year” article, 1999. [3]
This work was foundational in the field of embryonic stem cells and stem cell research. Stevens' later studies focused on developing mouse models for the testing of chemotherapeutic drugs. and retired from the Laboratory in 1989. [1] [2] In 2015, at the age of 94, he died of congestive respiratory failure. [1]
For over 90 years, hematopoietic stem cell transplantation (HSCT) has been used to treat people with conditions such as leukaemia and lymphoma; this is the only widely practiced form of stem-cell therapy. [94] [97] [98] As of 2016, the only established therapy using stem cells is hematopoietic stem cell transplantation. [99]
Sean J. Morrison is a Canadian-American stem cell biologist and cancer researcher. Morrison is the director of Children's Medical Center Research Institute at UT Southwestern (CRI), [1] a nonprofit research institute established in 2011 as a joint venture between Children’s Health System of Texas and UT Southwestern Medical Center.
Wnt-1 was later discovered to be a key player in the stem cell self-renewal pathway. [8] She joined the biotech company SyStemix from 1989 to 1997, [9] where she co-discovered the human hematopoietic stem cell (hHSC) and played a leading role in the launch of the clinical research program for this cell. The purified hHSC was shown to be cancer ...
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