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α-Linolenic acid, also known as alpha-linolenic acid (ALA) (from Greek alpha meaning "first" and linon meaning flax), is an n−3, or omega-3, essential fatty acid. ALA is found in many seeds and oils, including flaxseed , walnuts , chia , hemp , and many common vegetable oils .
A 2019 review found that omega−3 supplements have no effect on prevention and treatment of type 2 diabetes. [168] [169] A 2021 meta-analysis found that supplementation with omega−3 had positive effects on diabetes biomarkers, such as fasting blood glucose and insulin resistance. [170]
Omega−3 fatty acids are important for normal metabolism. [ 2 ] Mammals are unable to synthesize omega−3 fatty acids, but can obtain the shorter-chain omega−3 fatty acid ALA (18 carbons and 3 double bonds) through diet and use it to form the more important long-chain omega−3 fatty acids, EPA (20 carbons and 5 double bonds) and then from ...
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ALA can be converted into eicosapentaenoic acid and docosahexaenoic acid, but the conversion amount is small, requiring intake from food or supplements. [1] Deficiency in omega−3 fatty acids are very common. The average American has a dietary ratio between omega−6 fatty acids and omega−3 fatty acids of 20:1.
Omega−3-carboxylic acids are used in addition to changes in diet to reduce triglyceride levels in adults with severe (≥ 500 mg/dL) hypertriglyceridemia. [6]Intake of large doses (2.0 to 4.0 g/day) of long-chain omega−3 fatty acids as prescription drugs or dietary supplements are generally required to achieve significant (> 15%) lowering of triglycerides, and at those doses the effects ...
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