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The related to receptor tyrosine kinase (RYK) gene encodes the protein Ryk. The protein encoded by this gene is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains.
The ErbB protein family or epidermal growth factor receptor (EGFR) family is a family of four structurally related receptor tyrosine kinases. Insufficient ErbB signaling in humans is associated with the development of neurodegenerative diseases , such as multiple sclerosis and Alzheimer's disease . [ 12 ]
Protein tyrosine kinase plays a role in this task, too. A protein tyrosine kinase called pp125, also referred to as focal adhesion kinase (FAK) is likely at hand in the influence of cellular focal adhesions, as indicated by an immunofluorescent localization of FAK. Focal adhesions are macromolecular structures that function in the transmission ...
6850 20963 Ensembl ENSG00000165025 ENSMUSG00000021457 UniProt P43405 P48025 RefSeq (mRNA) NM_001135052 NM_001174167 NM_001174168 NM_003177 NM_001198977 NM_011518 RefSeq (protein) NP_001128524 NP_001167638 NP_001167639 NP_003168 NP_001185906 NP_035648 Location (UCSC) Chr 9: 90.8 – 90.9 Mb Chr 13: 52.74 – 52.8 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Tyrosine-protein kinase ...
Protein Wnt-5a is a protein that in humans is encoded by the WNT5A gene. [5] [6] ... However, non-canonical Wnt5a has also been shown to bind to Ror1/2, RYK, and RTK ...
18214 Ensembl ENSG00000162733 ENSMUSG00000026674 UniProt Q16832 Q62371 RefSeq (mRNA) NM_001014796 NM_006182 NM_001354982 NM_001354983 NM_022563 RefSeq (protein) NP_001014796 NP_006173 NP_001341911 NP_001341912 NP_072075 Location (UCSC) Chr 1: 162.63 – 162.79 Mb Chr 1: 169.8 – 169.94 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Discoidin domain-containing receptor 2, also known ...
Trk receptors affect neuronal growth and differentiation through the activation of different signaling cascades. The three known pathways are PLC, Ras/MAPK (mitogen-activated protein kinase) and the PI3K (phosphatidylinositol 3-kinase) pathways. [3] These pathways involve the interception of nuclear and mitochondrial cell-death programs. [3]
Src kinase family is a family of non-receptor tyrosine kinases that includes nine members: Src, Yes, Fyn, and Fgr, forming the SrcA subfamily, Lck, Hck, Blk, and Lyn in the SrcB subfamily, and Frk in its own subfamily.
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