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More women may benefit from gene testing for hereditary breast or ovarian cancer, ... At issue are genes called BRCA1 and BRCA2. When they're mutated, the body can't repair damaged DNA as well ...
Breast and ovarian cancers: Medicare may cover genetic testing to determine if a person has a mutation in the BRCA1 and BRCA2 genes, which can help identify their risk of breast and ovarian cancers.
There is likely little or no effect of a BRCA gene mutation on overall fertility, [19] although women with a BRCA mutation may be more likely to have primary ovarian insufficiency. [20] [21] BRCA mutation carriers may be more likely to give birth to girls than boys, [22] however this observation has been attributed to ascertainment bias. [23] [24]
A guide to finding out your breast cancer risk, and whether you should be tested for BRCA mutations.
Genetic testing, also known as DNA testing, is used to identify changes in DNA sequence or chromosome structure. Genetic testing can also include measuring the results of genetic changes, such as RNA analysis as an output of gene expression , or through biochemical analysis to measure specific protein output. [ 1 ]
Mutations of the genes BRCA1 and BRCA2 can increase the risk of breast cancer in the patients lifetime. In the US, risk factors for breast cancer like the BRCA gene and age are taken into consideration to decide if a screening test is needed and if so which is best for the person. [25]
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The National Comprehensive Cancer Network (NCCN) guidelines recommend bilateral prophylactic mastectomy and bilateral salpingo-oophorectomy for women who are carriers of germline BRCA1/2 mutation. At the age of 35 to 40 years, or once childbearing is completed, the procedure is recommended for risk reduction purposes.
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