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Leflunomide, sold under the brand name Arava among others, is an immunosuppressive disease-modifying antirheumatic drug , [8] used in active moderate-to-severe rheumatoid arthritis and psoriatic arthritis. It is a pyrimidine synthesis inhibitor that works by inhibiting dihydroorotate dehydrogenase. [9] Bottle of Leflunomide (Arava) and tablet
The most commonly used agent is methotrexate with other frequently used agents including sulfasalazine and leflunomide. [8] Leflunomide is effective when used from 6–12 months, with similar effectiveness to methotrexate when used for 2 years. [120] Sulfasalazine also appears to be most effective in the short-term treatment of rheumatoid ...
In December 2002 Steiner Leisure Limited became the sole owner of Mandara Spa after acquiring the 40% equity interests from Shiseido. Steiner Leisure Limited is a global provider of spa services and operations, a manufacturer and distributor of skin, body and hair care products and an accredited educator teaching massage, skincare, and spa management.
Ideal sources for Wikipedia's health content are defined in the guideline Wikipedia:Identifying reliable sources (medicine) and are typically review articles. Here are links to possibly useful sources of information about Leflunomide. PubMed provides review articles from the past five years (limit to free review articles)
Although the use of the term DMARDs was first propagated in rheumatoid arthritis (hence their name), the term has come to pertain to many other diseases, such as Crohn's disease, lupus erythematosus, Sjögren syndrome, immune thrombocytopenic purpura, myasthenia gravis, sarcoidosis, and various others.
Full Body Massage is a 1995 American drama television film directed by Nicolas Roeg, written by Dan Gurskis, starring Mimi Rogers and Bryan Brown. [1] In the film, an art dealer talks about relationships and philosophy with her masseur.
Thai massage combines both physical and energetic aspects. It is a deep, full-body massage progressing from the feet up, and focusing on sen or energy lines throughout the body, with the aim of clearing blockages in these lines, and thus stimulating the flow of blood and lymph throughout the body. It draws on yoga, acupressure and reflexology.
This is considered a simple structural modification and a technically simple one-step synthetic transformation. Upon oral administration of leflunomide in vivo, the isoxazole ring of leflunomide is opened and teriflunomide is formed. [15] Teriflunomide is the only active metabolite of leflunomide, completely responsible for its therapeutic actions.