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Of the 660,000 congenital syphilis cases reported in 2016, 143,000 resulted in deaths of unborn babies, 61,000 deaths of newborn babies, 41,000 low birth weights or preterm births, and 109,000 young children diagnosed with congenital syphilis. [15] Around 75% were from the WHO's African and Eastern Mediterranean regions. [2]
Treatment at this stage solely limits further progression of the disease and has a limited effect on damage which has already occurred. [3] Serologic cure can be measured when the non-treponemal titers decline by a factor of 4 or more in 6–12 months in early syphilis or 12–24 months in late syphilis. [21]
Since 1990, when the vaccine was introduced as a routine vaccination in children, rates of acute Hepatitis B has decreased in the United States by 82%. This vaccine is given as a series of shots, the first dose is given at birth, the second between 1 and 2 months, and the third, and possibly fourth, between 6 and 18 months.
CDC says that more than 3,700 cases of congenital syphilis were reported in 2022, around 11 times the number recorded a decade ago ... could have been prevented with testing and treatment ...
Arsphenamine was used to treat the disease syphilis because it is toxic to the bacterium Treponema pallidum, a spirochete that causes syphilis. [6] Arsphenamine was originally called "606" because it was the sixth in the sixth group of compounds synthesized for testing; it was marketed by Hoechst AG under the trade name "Salvarsan" in 1910.
Michigan saw a 200% increase in the rate of congenital syphilis from 2017-2021, as a rising number of babies in the U.S. are born with the infection.
Syphilis rates in Texas continue to climb, alarming healthcare workers who see the highest increases among pregnant people and newborns. A shortage of treatment is complicating efforts to combat it.
Many of the syphilis treatment therapies only lead to bacteriostatic results, unless larger concentrations of penicillin are used for bactericidal effects. [ 65 ] [ 66 ] Penicillin overall is the most recommended antibiotic by the Centers for Disease Control, as it shows the best results with prolonged use.
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