Search results
Results from the WOW.Com Content Network
In humans, the vitamin D receptor is encoded by the VDR gene located on chromosome 12q13.11. [7] VDR is expressed in most tissues of the body, and regulates transcription of genes involved in intestinal and renal transport of calcium and other minerals. [8] Glucocorticoids decrease VDR expression. [8] Many types of immune cells also express VDR ...
The VDR is widely distributed in tissues, and is not restricted to those tissues considered the classic targets of vitamin D. The VDR upon binding to 1,25(OH) 2 D heterodimerizes with other nuclear hormone receptors, in particular the family of retinoid X receptors. This VDR/RXR heterodimer complex binds to the specific VDRE in the promoters of ...
The VDR/RXR complex subsequently binds to vitamin D response elements (VDRE) which are specific DNA sequences adjacent to genes, numbers estimated as being in the thousands. The VDR/RXR/DNA complex recruits other proteins that transcribe the downstream gene into mRNA which in turn is translated into protein causing a change in cell function. [3 ...
The light chain genes possess either a single (Cκ) or four (Cλ) Constant gene segments with numerous V and J gene segments but do not have D gene segments. [3] DNA rearrangement causes one copy of each type of gene segment to go in any given lymphocyte, generating an enormous antibody repertoire; roughly 3×10 11 combinations are possible ...
The Gene: An Intimate History is a book written by Siddhartha Mukherjee, an Indian-born American physician and oncologist. It was published on 17 May 2016 by Scribner . [ 1 ] The book chronicles the history of the gene and genetic research, all the way from Aristotle to Crick , Watson and Franklin and then the 21st century scientists who mapped ...
William French Anderson (born December 31, 1936) is an American physician, geneticist and molecular biologist.He is known as the "father of gene therapy".He graduated from Harvard College in 1958, Trinity College, Cambridge University (England) in 1960, and from Harvard Medical School in 1963.
19885 Ensembl ENSG00000143365 ENSMUSG00000028150 UniProt P51449 P51450 RefSeq (mRNA) NM_001001523 NM_005060 NM_001293734 NM_011281 RefSeq (protein) NP_001001523 NP_005051 NP_001280663 NP_035411 Location (UCSC) Chr 1: 151.81 – 151.83 Mb Chr 3: 94.28 – 94.31 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse RAR-related orphan receptor gamma (RORγ) is a protein that in humans is ...
Here, each gene has similar though slightly diverged function. For example, the human major histocompatibility complex (MHC) region is a complex of tightly linked genes all acting in the immune system, but has no claim to be a supergene, even though the component genes very likely have epistatic effects and are in strong disequilibrium due in ...