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Apoptosis regulator BAX, also known as bcl-2-like protein 4, is a protein that in humans is encoded by the BAX gene. [5] BAX is a member of the Bcl-2 gene family.BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities.
Bax/Bak are believed to initiate apoptosis by forming a pore in the mitochondrial outer membrane that allows cytochrome c to escape into the cytoplasm and activate the pro-apoptotic caspase cascade. The anti-apoptotic Bcl-2 and Bcl-xL proteins inhibit cytochrome c release through the mitochondrial pore and also inhibit activation of the ...
Generally, the pro-apoptotic function of BAK1 contributes to neurodegenerative and autoimmune diseases when overexpressed and cancers when inhibited. [8] For instance, dysregulation of the BAK gene has been implicated in human gastrointestinal cancers, indicating that the gene plays a part in the pathogenesis of some cancers. [12] [13]
The AOL.com video experience serves up the best video content from AOL and around the web, curating informative and entertaining snackable videos.
Benzalkonium chloride (BZK, BKC, BAK, BAC), also known as alkyldimethylbenzylammonium chloride (ADBAC) and by the trade name Zephiran, [1] is a type of cationic surfactant. It is an organic salt classified as a quaternary ammonium compound. ADBACs have three main categories of use: as a biocide, a cationic surfactant, and a phase transfer agent ...
The design of the iPhone 14 Pro and iPhone 14 Pro Max is almost identical to older iPhone models, such as the iPhone 12 Pro and 13 Pro. The iPhone 14 Pro and iPhone 14 Pro Max have a new front camera called the Dynamic Island. The Dynamic Island can now bubble up alerts instead of having a notification.
Bcl-xL dysfunction in mice can cause ineffective production of red blood cells, severe anemia, hemolysis, and death. This protein has also been shown as a requirement for heme production [6] and in erythroid lineage, Bcl-xL is a major survival factor responsible for an estimated half of the total survival "signal" proerythroblasts must receive in order to survive and become red cells.
In computing, ".bak" is a filename extension commonly used to signify a backup copy of a file. When a program is about to overwrite an existing file (for example, when the user saves the document they are working on), the program may first make a copy of the existing file, with .bak appended to the filename.