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GLUTs are integral membrane proteins that contain 12 membrane-spanning helices with both the amino and carboxyl termini exposed on the cytoplasmic side of the plasma membrane. GLUT proteins transport glucose and related hexoses according to a model of alternate conformation, [5] [6] [7] which predicts that the transporter exposes a single ...
It is an integral membrane protein carrier with a hydrophilic interior, which allows it to bind to glucose. As GLUT 1 is a type of carrier protein, it will undergo a conformational change to allow glucose to enter the other side of the plasma membrane. [22] GLUT 1 is commonly found in the red blood cell membranes of mammals. [23]
Glucose uptake is the process by which glucose molecules are transported from the bloodstream into cells through specialized membrane proteins called glucose transporters, primarily via facilitated diffusion or active transport mechanisms: [1]
Glucose transporter type 4 (GLUT4), also known as solute carrier family 2, facilitated glucose transporter member 4, is a protein encoded, in humans, by the SLC2A4 gene. GLUT4 is the insulin -regulated glucose transporter found primarily in adipose tissues and striated muscle (skeletal and cardiac).
The glucose transporter is specialized in transporting glucose specifically across the membrane. The GLUT proteins have several types of isoforms, each distributed in different tissues and exhibiting different kinetic properties. [16] Glucose transporter. GLUTs are integral membrane proteins composed of 12 α-helix membrane spanning regions. [16]
The gene was then discovered for intestinal glucose transport protein and linked to these membrane sodium glucose cotransport systems. The first of these membrane transport proteins was named SGLT1 followed by the discovery of SGLT2. [7] Robert Krane also played a prominent role in this field.
n/a Ensembl n/a n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) n/a n/a PubMed search n/a n/a Wikidata View/Edit Human Glut2basal.png Glucose transporter 2 (GLUT2) also known as solute carrier family 2 (facilitated glucose transporter), member 2 (SLC2A2) is a transmembrane carrier protein that enables protein facilitated glucose movement across cell membranes ...
227659 Ensembl ENSG00000160326 ENSG00000281165 ENSMUSG00000036067 UniProt Q9UGQ3 Q3UDF0 RefSeq (mRNA) NM_001145099 NM_017585 NM_001177627 NM_172659 RefSeq (protein) NP_001138571 NP_060055 NP_001171098 NP_766247 Location (UCSC) Chr 9: 133.47 – 133.48 Mb Chr 2: 26.91 – 26.92 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Solute carrier family 2, facilitated glucose transporter ...