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Kidney stones are primarily composed of calcium salts, with the most common being calcium oxalate (70-80%), followed by calcium phosphate and uric acid. When urine contains high concentrations of these ions, they can form crystals and eventually stones. [41] The formation of kidney stones occurs in three main phases: [41]
Between 1% and 15% of people globally are affected by kidney stones at some point. [14] [15] In 2015, they caused about 16,000 deaths worldwide. [16] Some of the oxalate in urine is produced by the body. Calcium and oxalate in the diet play a part but are not the only factors that affect the formation of calcium oxalate stones.
Members of the spinach family and the brassicas (cabbage, broccoli, brussels sprouts) are high in oxalates, as are sorrel and umbellifers like parsley. [37] The leaves and stems of all species of the genus Chenopodium and related genera of the family Amaranthaceae , which includes quinoa , contain high levels of oxalic acid. [ 38 ]
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The agency warned that consumption of aristolochic acid-containing products was associated with "permanent kidney damage, sometimes resulting in kidney failure that has required kidney dialysis or kidney transplantation. In addition, some patients have developed certain types of cancers, most often occurring in the urinary tract." [24]
Oxalate oxidase （Enzyme Commission number EC 1.2.3.4 [2] ）occurs mainly in plants. It can degrade oxalic acid into carbon dioxide and hydrogen peroxide. [3]Oxalate decarboxylase (OXDC，EC 4.1.1.2) is a kind of oxalate degrading enzyme containing Mn 2+, [4] found mainly in fungi or some bacteria.
Mayo Clinic Health System's Eau Claire hospital was ranked number 6 in the state of Wisconsin in 2020, and 4th in 2021 by U.S. News & World Report. [43] In 2021 and 2022, the health system's Albert Lea-Austin hospital, and La Crosse hospital were included in Newsweek 's list of top U.S. hospitals.
One of the first uses of the diamond engagement or wedding ring is for the marriage of Maximilian I, then Archduke of Austria, to Mary of Burgundy in 1477. [59] Other early examples of betrothal jewels incorporating diamonds include the Bridal Crown of Blanche ( c. 1370–1380) [ 59 ] and the Heftlein brooch of Vienna ( c. 1430–1440), [ 59 ...
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