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The bronchioles (/ ˈ b r ɑː ŋ k i oʊ l s / BRONG-kee-ohls) are the smaller branches of the bronchial airways in the lower respiratory tract.They include the terminal bronchioles, and finally the respiratory bronchioles that mark the start of the respiratory zone delivering air to the gas exchanging units of the alveoli.
The receptors are less abundant in the distal airways and absent beyond the respiratory bronchioles. When triggered, impulses travel via the internal laryngeal nerve, a branch of the superior laryngeal nerve which stems from the vagus nerve (CN X) to the medulla of the brain. This is the afferent neural pathway.
Anatomical dead space is the volume of the conducting airways (from the nose, mouth and trachea to the terminal bronchioles). These conduct gas to the alveoli but no gas exchange occurs here. In healthy lungs where the alveolar dead space is small, Fowler's method accurately measures the anatomic dead space using a single breath nitrogen ...
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Moving down the bronchioles, the cells get more cuboidal in shape but are still ciliated. Glands are abundant in the upper respiratory tract, but there are fewer lower down and they are absent starting at the bronchioles. The same goes for goblet cells, although there are scattered ones in the first bronchioles.
From week 16 to week 26, the bronchi enlarge and lung tissue becomes highly vascularised. Bronchioles and alveolar ducts also develop. By week 26, the terminal bronchioles have formed which branch into two respiratory bronchioles. [59] During the period covering the 26th week until birth the important blood–air barrier is established.
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The cells in the respiratory epithelium are of five main types: a) ciliated cells, b) goblet cells, c) brush cells, d) airway basal cells, and e) small granule cells (NDES) [6] Goblet cells become increasingly fewer further down the respiratory tree until they are absent in the terminal bronchioles; club cells take over their role to some extent here. [7]