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Eosinophilia–myalgia syndrome is a rare, sometimes fatal neurological condition linked to the ingestion of the dietary supplement L-tryptophan. [1] [2] The risk of developing EMS increases with larger doses of tryptophan and increasing age. [3]
A cancer vaccine, or oncovaccine, is a vaccine that either treats existing cancer or prevents development of cancer. [1] Vaccines that treat existing cancer are known as therapeutic cancer vaccines or tumor antigen vaccines. Some of the vaccines are "autologous", being prepared from samples taken from the patient, and are specific to that patient.
Tryptophan ball and stick model spinning. Tryptophan (symbol Trp or W) [3] is an α-amino acid that is used in the biosynthesis of proteins.Tryptophan contains an α-amino group, an α-carboxylic acid group, and a side chain indole, making it a polar molecule with a non-polar aromatic beta carbon substituent.
[8]: 327–328 Multiple epidemiological studies [7] [9] [10] traced an outbreak of eosinophilia-myalgia syndrome (EMS) to L-tryptophan supplied by Showa Denko, which resulted in 37 deaths. [11] [12] It was further hypothesized that one or more trace impurities produced during the manufacture of tryptophan may have been responsible for the EMS ...
1-Methyltryptophan is a chemical compound that is an inhibitor of the tryptophan catabolic enzyme indoleamine 2,3-dioxygenase (IDO or INDO EC 1.13.11.52). [1] It is a chiral compound that can exist as both D - and L-enantiomers. The L-isomer (L-1MT) inhibits IDO weakly but also serves as an enzyme substrate.
In cancer vaccines, the goal is to generate an immune response to these antigens through a vaccine. Currently, only one vaccine ( sipuleucel-T for prostate cancer) has been approved. In cell-mediated therapies like CAR-T cell therapy, immune cells are extracted from the patient, genetically engineered to recognize tumor-specific antigens, and ...
Familial hypertryptophanemia has an autosomal recessive pattern of inheritance.. Hypertryptophanemia is believed to be inherited in an autosomal recessive manner. [2] This means a defective gene responsible for the disorder is located on an autosome, and two copies of the defective gene (one inherited from each parent) are required in order to be born with the disorder.
121278 216343 Ensembl ENSG00000139287 ENSMUSG00000006764 UniProt Q8IWU9 Q8CGV2 RefSeq (mRNA) NM_173353 NM_173391 RefSeq (protein) NP_775489 NP_775567 Location (UCSC) Chr 12: 71.94 – 72.19 Mb Chr 10: 114.91 – 115.02 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Tryptophan hydroxylase 2 (TPH2) is an isozyme of tryptophan hydroxylase found in vertebrates. In humans, TPH2 is ...