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Aspartic acid ball and stick model spinning. Aspartic acid (symbol Asp or D; [4] the ionic form is known as aspartate), is an α-amino acid that is used in the biosynthesis of proteins. [5] The L-isomer of aspartic acid is one of the 22 proteinogenic amino acids, i.e., the building blocks of proteins.
FDPB-based methods calculate the change in the pK a value of an amino acid side chain when that side chain is moved from a hypothetical fully solvated state to its position in the protein. To perform such a calculation, one needs theoretical methods that can calculate the effect of the protein interior on a p K a value, and knowledge of the pKa ...
Amino acid Short Abbrev. Side chain Hydro-phobic pKa § Polar pH Small Tiny Aromatic or Aliphatic van der Waals volume (Å 3) Alanine: A Ala -CH 3 - - Aliphatic 67 Cysteine: C Cys -CH 2 SH: 8.55 acidic - 86 Aspartic acid: D Asp -CH 2 COOH 3.67 acidic - 91 Glutamic acid: E Glu -CH 2 CH 2 COOH 4.25 acidic - 109 Phenylalanine: F Phe -CH 2 C 6 H 5 ...
A salt bridge in T4 lysozyme between aspartic acid (Asp) at residue 70 and a histidine (His) at residue 31. The contribution of a salt bridge to the overall stability to the folded state of a protein can be assessed through thermodynamic data gathered from mutagenesis studies and nuclear magnetic resonance techniques. [13]
Asparagine also provides key sites for N-linked glycosylation, modification of the protein chain with the addition of carbohydrate chains. Typically, a carbohydrate tree can solely be added to an asparagine residue if the latter is flanked on the C side by X-serine or X-threonine, where X is any amino acid with the exception of proline. [19]
Chemical formula: C 4 H 7 N O 4 ... (DL)/(RS)}-Aspartic acid CHEBI:22660 CHEMBANK2882 CPD-302 NSC141379 NSC167399 NSC3973 NSC620336 NSC79553 NSC97922 Spartase ...
Lysine. Technically, any organic compound with an amine (–NH 2) and a carboxylic acid (–COOH) functional group is an amino acid. The proteinogenic amino acids are a small subset of this group that possess a central carbon atom (α- or 2-) bearing an amino group, a carboxyl group, a side chain and an α-hydrogen levo conformation, with the exception of glycine, which is achiral, and proline ...
It consists of three amino acid residues (labeled i, i+1 and i+2) in which residue i is an aspartate (Asp) or asparagine (Asn) that forms a hydrogen bond from its sidechain CO group to the mainchain NH group of residue i+2. About 14% of Asx residues present in proteins belong to Asx turns.