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Bilirubin (BR) (from the Latin for "red bile") is a red-orange compound that occurs in the normal catabolic pathway that breaks down heme in vertebrates.This catabolism is a necessary process in the body's clearance of waste products that arise from the destruction of aged or abnormal red blood cells. [3]
The bilirubin present in the plasma is largely unconjugated in this setting as they haven't been taken up and conjugated by the liver. [3] In this case, total serum bilirubin increases while the ratio of direct bilirubin to indirect bilirubin remains 96 to 4 as up to 96%-99% of bilirubin in the bile are conjugated mentioned above. [9] [1]
When total bilirubin levels exceed 40 μmol/L, bilirubin deposition at the sclera, skin, and mucous membranes will give these areas a yellow colour, thus it is called jaundice. [6] The increase in predominantly unconjugated bilirubin is due to overproduction, reduced hepatic uptake of the unconjugated bilirubin and reduced conjugation of bilirubin.
Bilirubin di-glucuronide is a conjugated form of bilirubin formed in bilirubin metabolism. [1] The hydrophilic character of bilirubin diglucuronide enables it to be water-soluble. It is pumped across the hepatic canalicular membrane into the bile by the transporter MRP2 .
The former, referring to elevated unconjugated bilirubin, is often caused by haemolytic diseases resulting in increased bilirubin production and impaired bilirubin conjugation. The latter is often attributed to direct hepatocyte injury that impedes conjugated bilirubin secretion. [6]
Spanish verbs are conjugated in three persons, each having a singular and a plural form. In some varieties of Spanish, such as that of the Río de la Plata Region, a special form of the second person is used. Spanish is a pro-drop language, meaning that subject pronouns are often omitted.
Reverso is a French company specialized in AI-based language tools, translation aids, and language services. [2] These include online translation based on neural machine translation (NMT), contextual dictionaries, online bilingual concordances, grammar and spell checking and conjugation tools.
NEG se CL puede can. 1SG pisar walk el the césped grass No se puede pisar el césped NEG CL can.1SG walk the grass "You cannot walk on the grass." Zagona also notes that, generally, oblique phrases do not allow for a double clitic, yet some verbs of motion are formed with double clitics: María María se CL fue went.away- 3SG María se fue María CL went.away-3SG "Maria went away ...