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  2. Dimensional models of personality disorders - Wikipedia

    en.wikipedia.org/wiki/Dimensional_models_of...

    Dimensional models are intended to reflect what constitutes personality disorder symptomology according to a spectrum, rather than in a dichotomous way.As a result of this they have been used in three key ways; firstly to try to generate more accurate clinical diagnoses, secondly to develop more effective treatments and thirdly to determine the underlying etiology of disorders.

  3. Clostridioides difficile toxin A - Wikipedia

    en.wikipedia.org/wiki/Clostridioides_difficile...

    The toxins function by damaging the intestinal mucosa and cause the symptoms of C. difficile infection, including pseudomembranous colitis. TcdA is one of the largest bacterial toxins known. With a molecular mass of 308 kDa, it is usually described as a potent enterotoxin , [ 3 ] but it also has some activity as a cytotoxin . [ 4 ]

  4. Clostridioides difficile infection - Wikipedia

    en.wikipedia.org/wiki/Clostridioides_difficile...

    Signs and symptoms of CDI range from mild diarrhea to severe life-threatening inflammation of the colon. [16]In adults, a clinical prediction rule found the best signs to be significant diarrhea ("new onset of more than three partially formed or watery stools per 24-hour period"), recent antibiotic exposure, abdominal pain, fever (up to 40.5 °C or 105 °F), and a distinctive foul odor to the ...

  5. Clostridioides difficile toxin B - Wikipedia

    en.wikipedia.org/wiki/Clostridioides_difficile...

    There are different plasmid sizes of C. difficile. The detected molecular weights range from 2.7x10 6 to 100x10 6, but plasmid sizes show no correlation with toxicity. In order to detect the toxin B level in C. difficile, clinicians extensively use cell culture assays derived from stool specimens from patients with PMC.

  6. Personality disorder - Wikipedia

    en.wikipedia.org/wiki/Personality_disorder

    For example, in a study published in 2003 titled "The five-factor model and personality disorder empirical literature: A meta-analytic review", [65] the authors analyzed data from 15 other studies to determine how personality disorders are different and similar, respectively, with regard to underlying personality traits. In terms of how ...

  7. Big Five personality traits - Wikipedia

    en.wikipedia.org/wiki/Big_Five_personality_traits

    The Pathoplasty Model: This model proposes that premorbid personality traits impact the expression, course, severity, and/or treatment response of a mental disorder. [ 194 ] [ 200 ] [ 81 ] An example of this relationship would be a heightened likelihood of committing suicide in a depressed individual who also has low levels of constraint.

  8. Personality systematics - Wikipedia

    en.wikipedia.org/wiki/Personality_systematics

    Personality systematics is a contribution to the psychology of personality and to psychotherapy summarized by Jeffrey J. Magnavita in 2006 and 2009. [ 1 ] [ 2 ] It is the study of the interrelationships among subsystems of personality as they are embedded in the entire ecological system .

  9. Personality pathology - Wikipedia

    en.wikipedia.org/wiki/Personality_pathology

    Personality pathology refers to enduring patterns of cognition, emotion, and behavior that negatively affect a person's adaptation. In psychiatry and clinical psychology , it is characterized by adaptive inflexibility, vicious cycles of maladaptive behavior, and emotional instability under stress.

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