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Methylthioninium chloride, commonly called methylene blue, is a salt used as a dye and as a medication.As a medication, it is mainly used to treat methemoglobinemia by chemically reducing the ferric iron in hemoglobin to ferrous iron.
For this test, the patient takes oral phenazopyridine (Pyridium) 200 mg three times a day, and indigo carmine or methylene blue is filled into the empty urinary bladder via a urethral catheter. Pyridium turns urine orange in the kidneys, and methylene blue (or indigo carmine) turns urine blue in the bladder. [1] A tampon is placed into the ...
[20] A separate list for children up to 12 years of age, known as the WHO Model List of Essential Medicines for Children (EMLc), was created in 2007 and is in its 9th edition. [10] [21] [22] [23] It was created to make sure that the needs of children were systematically considered such as availability of proper formulations.
Although the response is usually rapid, the dose may be repeated in one hour if the level of methemoglobin is still high one hour after the initial infusion. Methylene blue inhibits monoamine oxidase, and serotonin toxicity can occur if taken with an SSRI (selective serotonin reuptake inhibitor) medicine. [20] Methylene blue restores the iron ...
Methylene blue (methylthioninium chloride), the antidote indicated for drug-induced methemoglobinemia on the World Health Organization's List of Essential Medicines, among a plethora of other off-label uses, is a highly potent, reversible MAO inhibitor. [53] The Food and Drug Administration (FDA) has approved these MAOIs to treat depression: [54]
New methylene blue (also NMB) [clarify] is an organic compound of the thiazine class of heterocycles. It is used as a stain and as an antimicrobial agent. It is classified as an azine dye, and the chromophore is a cation, the anion is often unspecified.
The disorder can cause heart abnormalities and seizures if the amount of methemoglobin in the blood exceeds 20 percent, but at levels between 10 and 20 percent it can cause blue skin without other symptoms. Most of the Fugates lived long and healthy lives. The "bluest" of the blue Fugates, Luna Stacy, had 13 children and lived to age 84. [6]
Allergic-like reactions and methemoglobinemia have been documented after the use of methylene blue dye in chromopertubation. [9] These reported symptoms vary from blue discoloration of body fluids to anaphylactic shock. [10] Methemoglobinemia is a blood disorder that can potentially result in various levels of cyanosis. [11]
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