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A calibration curve plot showing limit of detection (LOD), limit of quantification (LOQ), dynamic range, and limit of linearity (LOL).. In analytical chemistry, a calibration curve, also known as a standard curve, is a general method for determining the concentration of a substance in an unknown sample by comparing the unknown to a set of standard samples of known concentration. [1]
The figure below illustrates the relationship between the blank, the limit of detection (LOD), and the limit of quantitation (LOQ) by showing the probability density function for normally distributed measurements at the blank, at the LOD defined as 3 × standard deviation of the blank, and at the LOQ defined as 10 × standard deviation of the ...
In a confirmatory or primary screen with replicates, for the i-th test compound with replicates, we calculate the paired difference between the measured value (usually on the log scale) of the compound and the median value of a negative control in a plate, then obtain the mean ¯ and variance of the paired difference across replicates.
To determine an appropriate sample size n for estimating proportions, the equation below can be solved, where W represents the desired width of the confidence interval. The resulting sample size formula, is often applied with a conservative estimate of p (e.g., 0.5): = /
In statistics, deviance is a goodness-of-fit statistic for a statistical model; it is often used for statistical hypothesis testing.It is a generalization of the idea of using the sum of squares of residuals (SSR) in ordinary least squares to cases where model-fitting is achieved by maximum likelihood.
The MLD of household income has been defined as [1] = = ¯ where N is the number of households, is the income of household i, and ¯ is the mean of .Naturally the same formula can be used for positive variables other than income and for units of observation other than households.
A tolerance interval (TI) is a statistical interval within which, with some confidence level, a specified sampled proportion of a population falls. "More specifically, a 100×p%/100×(1−α) tolerance interval provides limits within which at least a certain proportion (p) of the population falls with a given level of confidence (1−α)."
For example, to calculate the 95% prediction interval for a normal distribution with a mean (μ) of 5 and a standard deviation (σ) of 1, then z is approximately 2. Therefore, the lower limit of the prediction interval is approximately 5 ‒ (2⋅1) = 3, and the upper limit is approximately 5 + (2⋅1) = 7, thus giving a prediction interval of ...